The emergence and spread of antibiotic resistance among pathogenic bacteria has been a
rising problem for public health in recent decades. It is becoming increasingly recognized …

The overuse of veterinary antibiotics in animal production and the subsequent land
applications of manures contribute to the elevated antibiotic resistance in the soil …

There is increasing public concern regarding the fate of antibiotic resistance genes (ARGs)
during wastewater treatment, their persistence during the treatment process and their …

Antibiotic resistance is a serious global threat for public health. Considering the high
abundance of cell-free DNA encoding antibiotic resistance genes (ARGs) in both clinical …

Aquaculture uses hundreds of tonnes of antimicrobials annually to prevent and treat
bacterial infection. The passage of these antimicrobials into the aquatic environment selects …

Integrons are versatile gene acquisition systems commonly found in bacterial genomes.
They are ancient elements that are a hot spot for genomic complexity, generating phenotypic …

It has been hypothesized that some antibiotic resistance genes (ARGs) found in pathogenic
bacteria derive from antibiotic-producing actinobacteria. Here we provide bioinformatic and …

Evolution is the hallmark of life. Descriptions of the evolution of microorganisms have
provided a wealth of information, but knowledge regarding “what happened” has precluded …

The worldwide growth of aquaculture has been accompanied by a rapid increase in
therapeutic and prophylactic usage of antimicrobials including those important in human …

Bacterial resistance is a rapidly escalating threat to public health as our arsenal of effective
antibiotics dwindles. Therefore, there is an urgent need for new antibiotics. Drug discovery …