In this review, advances in the understanding of epigenetic reprogramming from fertilization
to the development of primordial germline cells in a mouse and human embryo are …

The mammalian embryo exhibits a remarkable plasticity that allows it to correct for the
presence of aberrant cells, adjust its growth so that its size is in accordance with its …

The combination of genome editing and primordial germ cell (PGC) transplantation has
enormous significance in the study of developmental biology and genetic breeding, despite …

Human primordial germ cells (hPGCs) form around the time of implantation and are the
precursors of eggs and sperm. Many aspects of hPGC specification remain poorly …

Germ cells are essential to pass DNA from one generation to the next. In human
reproduction, germ cell development begins with the specification of primordial germ cells …

The germline cells are essential for the propagation of human beings, thus essential for the
survival of mankind. The germline stem cells, as a unique cell type, generate various states …

Progress in understanding early human development has been impeded by the scarcity of
reference datasets from natural embryos, particularly those with spatial information during …

Germline development varies significantly across metazoans. However, mammalian
primordial germ cell (PGC) development has key conserved landmarks, including a critical …

In vivo and in vitro studies demonstrate that mitochondria in the oocyte, are susceptible to
damage by suboptimal pre/pregnancy conditions, such as obesity. These suboptimal …

In humans and other mammals, germline mutations are more likely to arise in fathers than in
mothers. Although this sex bias has long been attributed to DNA replication errors in …