Aims This joint document of the Italian Diabetes Society and the Italian Society of
Nephrology reviews the natural history of diabetic kidney disease (DKD) in the light of the …

Diabetic nephropathy (DN) is a common complication of Diabetes Mellitus (DM) Types 1 and
2, and prevention of end stage renal disease (ESRD) remains a major challenge. Despite its …

Diabetic kidney disease (DKD) is the leading cause of end stage renal disease (ESRD) in
the USA. The pathogenesis of DKD is multifactorial and involves activation of multiple …

Cellular senescence is associated with renal disease progression, and accelerated tubular
cell senescence promotes the pathogenesis of renal fibrosis. However, the underlying …

Diabetic nephropathy (DN) is a frequent and severe complication of diabetes mellitus (DM).
Its diagnosis in incipient stages may allow prompt interventions and an improved prognosis …

Diabetic kidney disease is expected to increase rapidly over the coming decades with rising
prevalence of diabetes worldwide. Current measures of kidney function based on …

Objective. Although hypoalbuminemia is frequently found in most patients with diabetic
nephropathy (DN), its relationship to the severity and progression of DN remains largely …

Diabetic nephropathy (DN) is a common and serious complication of diabetes associated
with adverse outcomes of renal failure, cardiovascular disease, and premature mortality …

Premature senescence is a key process in the progression of diabetic nephropathy (DN).
Premature senescence of renal tubular epithelial cells (RTEC) in DN may result from the …

Abstract Significance: Hydrogen sulfide (H2S) has only recently gained recognition for its
physiological effects. It is synthesized widely in the mammalian tissues and regulates …