Efferocytosis in health and disease

AC Doran, A Yurdagul Jr, I Tabas - Nature Reviews Immunology, 2020 - nature.com
The clearance of apoptotic cells by professional and non-professional phagocytes—a
process termed 'efferocytosis'—is essential for the maintenance of tissue homeostasis …

New insights into the evasion of host innate immunity by Mycobacterium tuberculosis

Q Chai, L Wang, CH Liu, B Ge - Cellular & molecular immunology, 2020 - nature.com
Mycobacterium tuberculosis (Mtb) is an extremely successful intracellular pathogen that
causes tuberculosis (TB), which remains the leading infectious cause of human death. The …

Phagocytosis: a fundamental process in immunity

C Rosales, E Uribe-Querol - BioMed research international, 2017 - Wiley Online Library
One hundred years have passed since the death of Élie Metchnikoff (1845–1916). He was
the first to observe the uptake of particles by cells and realized the importance of this …

Phagocytosis: an immunobiologic process

S Gordon - Immunity, 2016 - cell.com
It has been a century since the death of Élie Metchnikoff, who championed the role of
phagocytosis in cellular immunity. Whereas others had observed the uptake of particles by …

Patterns, receptors, and signals: regulation of phagosome maturation

AM Pauwels, M Trost, R Beyaert, E Hoffmann - Trends in immunology, 2017 - cell.com
Recognition of microbial pathogens and dead cells and their phagocytic uptake by
specialized immune cells are essential to maintain host homeostasis. Phagosomes undergo …

Pathways of MHC I cross-presentation of exogenous antigens

FM Cruz, A Chan, KL Rock - Seminars in immunology, 2023 - Elsevier
Phagocytes, particularly dendritic cells (DCs), generate peptide-major histocompatibility
complex (MHC) I complexes from antigens they have collected from cells in tissues and …

Better together: current insights into phagosome-lysosome fusion

JA Nguyen, RM Yates - Frontiers in immunology, 2021 - frontiersin.org
Following phagocytosis, the nascent phagosome undergoes maturation to become a
phagolysosome with an acidic, hydrolytic, and often oxidative lumen that can efficiently kill …

Presentation of phagocytosed antigens by MHC class I and II

AR Mantegazza, JG Magalhaes, S Amigorena… - Traffic, 2013 - Wiley Online Library
Phagocytosis provides innate immune cells with a mechanism to take up and destroy
pathogenic bacteria, apoptotic cells and other large particles. In some cases, however …

Cross-presentation of exogenous antigens on MHC I molecules

JD Colbert, FM Cruz, KL Rock - Current opinion in immunology, 2020 - Elsevier
Highlights•Dendritic cells internalize exogenous antigens for cross-presentation on MHC
I.•MHC I cross-presentation allows immune surveillance of viral infection and …

The biology and underlying mechanisms of cross-presentation of exogenous antigens on MHC-I molecules

FM Cruz, JD Colbert, E Merino… - Annual review of …, 2017 - annualreviews.org
To monitor the health of cells, the immune system tasks antigen-presenting cells with
gathering antigens from other cells and bringing them to CD8 T cells in the form of peptides …