The Arabidopsis root has been the subject of intense research over the past decades. This
research has led to significantly improved understanding of the molecular mechanisms …

Mitosis and cytokinesis are undoubtedly the most spectacular parts of the cell cycle. Errors in
the choreography of these processes can lead to aneuploidy or genetic instability, fostering …

The appropriate timing of events that lead to chromosome segregation during mitosis and
cytokinesis is essential to prevent aneuploidy, and defects in these processes can contribute …

A great many cell types are necessary for the myriad capabilities of complex, multicellular
organisms. One interesting aspect of this diversity of cell type is that many cells in diploid …

Cambridge, Massachusetts 02142 mosomal configuration. In endoreplication cell cycles, or
endocycles, S Molecular studies from the past decade have revealed phases alternate with …

One does not often look to analytic cubism for insights into the control of the cell cycle, but
Pablo Picasso beautifully encapsulated the fundamentals when he said that “every act of …

Polyploid cells have genomes that contain multiples of the typical diploid chromosome
number and are found in many different organisms. Studies in a variety of animal and plant …

Exit from mitosis requires the inactivation of mitotic cyclin-dependent kinases (CDKs) by an
unknown mechanism. We show that the Cdc14 phosphatase triggers mitotic exit by three …

Key events in mitosis such as sister chromatid separation and subsequent inactivation of
cyclin-dependent kinase 1 are regulated by ubiquitin-dependent proteolysis. These events …

Polyploid cells, which contain multiple copies of the typically diploid genome, are
widespread in plants and animals. Polyploidization can be developmentally programmed or …