Globally, about 400 million people reside at terrestrial altitudes above 1500 m, and more
than 100 million lowlanders visit mountainous areas above 2500 m annually. The …

Take home figure Adapted from Bärtsch and Gibbs Physiological response to hypoxia. Life-
sustaining oxygen delivery, in spite of a reduction in the partial pressure of inhaled oxygen …

Cellular hypoxia is the common final pathway of brain injury that occurs not just after
asphyxia, but also when cerebral perfusion is impaired directly (eg, embolic stroke) or …

After ascent to high altitude (≥ 2500 m), the inability of the human body to adapt to the
hypobaric and hypoxia environment can induce tissue hypoxia, then a series of high altitude …

High altitude exposure is often accompanied by weight loss. Postulated mechanisms are a
reduction of nutritional energy intake, a reduction of intestinal energy uptake from impaired …

Oxygen is vital for cellular metabolism; therefore, the hypoxic conditions encountered at high
altitude affect all physiological functions. Acute hypoxia activates the adrenergic system and …

Background Millions of tourists and climbers visit high altitudes annually. Many
unsuspecting and otherwise healthy individuals may get sick when sojourning to these high …

The (patho-) physiological responses to hypoxia are highly heterogeneous between
individuals. In this review, we focused on the roles of sex differences, which emerge as …

Introduction Hypertension is a leading cause of cardiovascular disease, which is the cause
of one-third of global deaths and is a primary and rising contributor to the global disease …

Areas at high-altitude, annually attract millions of tourists, skiers, trekkers, and climbers. If not
adequately prepared and not considering certain ascent rules, a considerable proportion of …