Cell-penetrating peptides (CPPs) are a diverse group of peptides, typically composed of 4 to
40 amino acids, known for their unique ability to transport a wide range of substances—such …

Protein–protein interactions (PPIs) are central to the cellular signaling and regulatory
networks that underlie many physiological and pathophysiological processes. It is …

The synthetic peptide ERα17p (sequence: PLMIKRSKKNSLALSLT), which corresponds to
the 295–311 region of the human estrogen receptor α (ERα), induces apoptosis in breast …

Access to the three-dimensional (3D) structural information of macromolecules is of major
interest in both fundamental and applied research. Obtaining this experimental data can be …

The estrogen receptor α (ERα) corresponds to a large platform in charge of the recruitment
of a panel of molecules, including steroids and related heterocyclic derivatives …

The development and the use of fluorinated polyproline-type II (PPII) foldamers are still
underexplored. Herein, trifluoromethyl pseudoprolines have been incorporated into …

Polyproline I helical structures are often considered as the hidden face of their most famous
geminal sibling, Polyproline II, as PPI is generally spotted only within a conformational …

Protein structures are highly dynamic macromolecules. This dynamics is often analysed
through experimental and/or computational methods only for an isolated or a limited number …

Light-driven water oxidation in photosynthesis occurs at the oxygen-evolving center (OEC)
of photosystem II (PSII). Chloride ions (Cl−) are essential for oxygen evolution by PSII, and …

Human carbonic anhydrase IX (hCA IX) is a tumour-associated enzyme present in a limited
number of normal tissues, but overexpressed in several malignant human tumours. It is a …