Aging is typified by a progressive decline in mitochondrial activity and stress resilience.
Here, we review how mitochondrial stress pathways have pleiotropic effects on cellular and …

Mitochondria perform a myriad of essential functions that ensure organismal homeostasis,
including maintaining bioenergetic capacity, sensing and signalling the presence of …

The ability to balance conflicting functional demands is critical for ensuring organismal
survival. The transcription and repair of the mitochondrial genome (mtDNA) requires …

Mitochondrial proteases are emerging as key regulators of mitochondrial plasticity and
acting as both protein quality surveillance and regulatory enzymes by performing highly …

We review the findings that establish that perturbations of various aspects of mitochondrial
function, including oxidative phosphorylation, can promote lifespan extension, with different …

Perturbations of mitochondrial proteostasis have been associated with aging,
neurodegenerative diseases, and recently with hypoxic injury. While examining hypoxia …

The kidney is a mitochondria-rich organ, and kidney diseases are recognized as
mitochondria-related pathologies. Intact mitochondrial DNA (mtDNA) maintains normal …

Huntington's disease (HD) predominantly affects the brain, causing a mixed movement
disorder, cognitive decline and behavioural abnormalities. It also causes a peripheral …

As one of the most vital organelles within biological cells, mitochondria hold an
irreplaceable status and play crucial roles in various diseases. Research and therapies …

Aging is accompanied by a progressive decline in mitochondrial function, which in turn
contributes to a variety of age-related diseases. Counterintuitively, a growing number of …