New Benzamides as Multi-Targeted Compounds: A Study on Synthesis, AChE and BACE1 Inhibitory Activity and Molecular Docking
D Drozdowska, D Maliszewski, A Wróbel… - International Journal of …, 2023 - mdpi.com
The synthesis of eleven new and previously undescribed benzamides was designed. These
compounds were specifically projected as potential inhibitors of the enzymes …
compounds were specifically projected as potential inhibitors of the enzymes …
Discovery of blood-brain barrier permeable and orally bioavailable caffeine-based amide derivatives as acetylcholinesterase inhibitors
Caffeine is one of the privileged natural products that shows numerous effects on the central
nervous system. Herein, thirty-one caffeine-based amide derivatives were synthesized and …
nervous system. Herein, thirty-one caffeine-based amide derivatives were synthesized and …
Novel Para-Aminobenzoic Acid Analogs and Their Potential Therapeutic Applications
A “building block” is a key component that plays a substantial and critical function in the
pharmaceutical research and development industry. Given its structural versatility and ability …
pharmaceutical research and development industry. Given its structural versatility and ability …
N‐Benzyl piperidine Fragment in Drug Discovery
A Sharma, M Sharma, SB Bharate - ChemMedChem, 2024 - Wiley Online Library
The N‐benzyl piperidine (N‐BP) structural motif is commonly employed in drug discovery
due to its structural flexibility and three‐dimensional nature. Medicinal chemists frequently …
due to its structural flexibility and three‐dimensional nature. Medicinal chemists frequently …