Pannexin‐1 in the CNS: Emerging concepts in health and disease

AK Yeung, CS Patil, MF Jackson - Journal of neurochemistry, 2020 - Wiley Online Library
Abstract Pannexin‐1 (Panx1) is a large pore membrane channel with unique conduction
properties ranging from non‐selective ion permeability to the extracellular release of …

Gap junctions and connexins in microglia-related oxidative stress and neuroinflammation: perspectives for drug discovery

G Caruso, L Di Pietro, F Caraci - Biomolecules, 2023 - mdpi.com
Microglia represent the immune system of the brain. Their role is central in two phenomena,
neuroinflammation and oxidative stress, which are at the roots of different pathologies …

Sublaminar organization of the human subplate: developmental changes in the distribution of neurons, glia, growing axons and extracellular matrix

I Kostović, IŽ Išasegi, Ž Krsnik - Journal of anatomy, 2019 - Wiley Online Library
The objective of this paper was to collect normative data essential for analyzing the subplate
(SP) role in pathogenesis of developmental disorders, characterized by abnormal circuitry …

Interactions between neural progenitor cells and microglia in the subventricular zone: physiological implications in the neurogenic niche and after implantation in the …

ER Matarredona, R Talaverón… - Frontiers in cellular …, 2018 - frontiersin.org
The adult subventricular zone (SVZ) of the mammalian brain contains neural progenitor cells
(NPCs) that continuously produce neuroblasts throughout life. These neuroblasts migrate …

Brain Disorders and Chemical Pollutants: A Gap Junction Link?

M Mesnil, N Defamie, C Naus, D Sarrouilhe - Biomolecules, 2020 - mdpi.com
The incidence of brain pathologies has increased during last decades. Better diagnosis
(autism spectrum disorders) and longer life expectancy (Parkinson's disease, Alzheimer's …

Connexins and pannexins: new insights into microglial functions and dysfunctions

R Gajardo-Gómez, VC Labra… - Frontiers in molecular …, 2016 - frontiersin.org
Under physiological conditions, microglia adopt a resting phenotype associated with the
production of anti-inflammatory and neurotrophic factors. In response to a wide variety of …

Connexins and pannexins in neuronal development and adult neurogenesis

LA Swayne, SAL Bennett - BMC cell biology, 2016 - Springer
Connexins and pannexins share very similar structures and functions; they also exhibit
overlapping expression in many stages of neuronal development. Here, we review evidence …

Connexin-43 gap junctions are responsible for the hypothalamic tanycyte-coupled network

A Recabal, R Elizondo-Vega, C Philippot… - Frontiers in Cellular …, 2018 - frontiersin.org
Tanycytes are hypothalamic radial glia-like cells that form the basal wall of the third ventricle
(3V) where they sense glucose and modulate neighboring neuronal activity to control …

Antiproliferative effect of boldine on neural progenitor cells and on glioblastoma cells

E Jiménez-Madrona, CJ Morado-Díaz… - Frontiers in …, 2023 - frontiersin.org
Introduction The subventricular zone (SVZ) is a brain region that contains neural stem cells
and progenitor cells (NSCs/NPCs) from which new neurons and glial cells are formed during …

Connexins and pannexins in Alzheimer's disease

C Giaume, JC Sáez, W Song, L Leybaert, CC Naus - Neuroscience letters, 2019 - Elsevier
By 2040 neurodegenerative diseases will become the world's second leading cause of
death after cardiovascular disease (WHO). Major efforts are required to elucidate the …