Snake venom proteins that affect the haemostatic system can cause (a) lowering of blood
coagulability,(b) damage to blood vessels, resulting in bleeding,(c) secondary effects of …

Metalloproteinases are among the most abundant toxins in many Viperidae venoms. Snake
venom metalloproteinases (SVMPs) are the primary factors responsible for hemorrhage and …

Gene duplication is a key mechanism for the adaptive evolution and neofunctionalization of
gene families. Large multigene families often exhibit complex evolutionary histories as a …

Synergism is a significant phenomenon present in snake venoms that may be an evolving
strategy to potentiate toxicities. Synergism exists between different toxins or toxin complexes …

Venom variability is commonly reported for venomous snakes including Bothrops atrox.
Here, we compared the composition of venoms from B. atrox snakes collected at Amazonian …

The human body has a set of physiological processes, known as hemostasis, which keeps
the blood fluid and free of clots in normal vessels; in the case of vascular injury, this process …

The structures and functional activities of metalloproteinases from snake venoms have been
widely studied because of the importance of these molecules in envenomation. Batroxase …

Hemorrhage is the most prominent effect of snake venom metalloproteinases (SVMPs) in
human envenomation. The capillary injury is a multifactorial effect caused by hydrolysis of …

Cysteine-rich secretory proteins (CRISPs) are commonly described as part of the protein
content of snake venoms, nevertheless, so far, little is known about their biological targets …

A hemorrhagic metalloproteinase, named Batx-I, was isolated from the venom of Bothrops
atrox specimens (from Southeastern Colombian region) by a combination of CM-Sephadex …