Cells respond to hypoxia by shifting cellular processes from general housekeeping functions
to activating specialized hypoxia-response pathways. Oxygen plays an important role in …

Simple Summary In this review paper, we discuss potential new therapies for ischemic heart
disease (IHD), a leading cause of death and disability around the world. IHD results from a …

Withaferin A (WFA) is one of the most active steroidal lactones with reactive oxygen species
(ROS) modulating effects against several types of cancer. ROS regulation involves selective …

Aberrant alternative splicing (AS) of pre-mRNAs promotes the development and proliferation
of cancerous cells. Accordingly, we had previously observed higher levels of the aryl …

The aryl hydrocarbon receptor nuclear translocator (ARNT) is broadly involved in regulating
tumorigenesis by inducing genes that are involved in tumor growth and angiogenesis …

The dark side of protein is the region (s) where molecular conformation is unknown.
Intrinsically disordered proteins (IDPs) and intrinsically disordered protein regions (IDPRs) …

Glioblastoma (GBM) is the most aggressive and lethal brain tumor in adults. This study
aimed to investigate the functional significance of aryl hydrocarbon receptor nuclear …

Background Cryptocarya-derived crude extracts and their compounds have been reported to
have an antiproliferation effect on several types of cancers but their impact on oral cancer is …

The aryl hydrocarbon receptor nuclear translocator (ARNT) is involved in xenobiotic and
hypoxic responses, and we previously showed that ARNT also regulates nuclear factor-κB …

The metabolic changes in melanoma cells that are required for tumor metastasis have not
been fully elucidated. In this study, we show that the increase in glucose uptake and …