Size-Dependent In Vivo Transport of Nanoparticles: Implications for Delivery, Targeting, and Clearance
Understanding the in vivo transport of nanoparticles provides guidelines for designing
nanomedicines with higher efficacy and fewer side effects. Among many factors, the size of …
nanomedicines with higher efficacy and fewer side effects. Among many factors, the size of …
Concepts of nanoparticle cellular uptake, intracellular trafficking, and kinetics in nanomedicine
Nanoparticle-based therapeutics and diagnostics are commonly referred to as
nanomedicine and may significantly impact the future of healthcare. However, the clinical …
nanomedicine and may significantly impact the future of healthcare. However, the clinical …
[HTML][HTML] An update on oral drug delivery via intestinal lymphatic transport
Orally administered drug entities have to survive the harsh gastrointestinal environment,
penetrate the enteric epithelia and circumvent hepatic metabolism before reaching the …
penetrate the enteric epithelia and circumvent hepatic metabolism before reaching the …
Towards more accurate bioimaging of drug nanocarriers: turning aggregation-caused quenching into a useful tool
One of the current challenges in the monitoring of drug nanocarriers lies in the difficulties in
discriminating the carrier-bound signals from the bulk signals of probes. Environment …
discriminating the carrier-bound signals from the bulk signals of probes. Environment …
Absorption, distribution, metabolism, and excretion of nanocarriers in vivo and their influences
A Zhang, K Meng, Y Liu, Y Pan, W Qu, D Chen… - Advances in Colloid and …, 2020 - Elsevier
As one of the most promising and effective delivery systems for targeted controlled-release
drugs, nanocarriers (NCs) have been widely studied. Although the development of …
drugs, nanocarriers (NCs) have been widely studied. Although the development of …
[HTML][HTML] Current research trends of nanomedicines
Owing to the inherent shortcomings of traditional therapeutic drugs in terms of inadequate
therapeutic efficacy and toxicity in clinical treatment, nanomedicine designs have received …
therapeutic efficacy and toxicity in clinical treatment, nanomedicine designs have received …
Application of Förster Resonance Energy Transfer (FRET) technique to elucidate intracellular and In Vivo biofate of nanomedicines
Extensive studies on nanomedicines have been conducted for drug delivery and disease
diagnosis (especially for cancer therapy). However, the intracellular and in vivo biofate of …
diagnosis (especially for cancer therapy). However, the intracellular and in vivo biofate of …
[HTML][HTML] Receptor-mediated targeted drug delivery systems for treatment of inflammatory bowel disease: Opportunities and emerging strategies
Inflammatory bowel disease (IBD) is a chronic intestinal disease with painful clinical
manifestations and high risks of cancerization. With no curative therapy for IBD at present …
manifestations and high risks of cancerization. With no curative therapy for IBD at present …
Biological and intracellular fates of drug nanocrystals through different delivery routes: Recent development enabled by bioimaging and PK modeling
Abstract Nanocrystals have contributed to exciting improvements in the delivery of poorly
water-soluble drugs. The biological and intracellular fates of nanocrystals are currently …
water-soluble drugs. The biological and intracellular fates of nanocrystals are currently …
Drug nanocrystals: Fabrication methods and promising therapeutic applications
IS Mohammad, H Hu, L Yin, W He - International journal of pharmaceutics, 2019 - Elsevier
The drug nanocrystals (NCs) with unique physicochemical properties are now considered
as a promising drug delivery system for poorly water-soluble drugs. So far> 20 formulations …
as a promising drug delivery system for poorly water-soluble drugs. So far> 20 formulations …