The biology and functional importance of MAIT cells
DI Godfrey, HF Koay, J McCluskey, NA Gherardin - Nature immunology, 2019 - nature.com
In recent years, a population of unconventional T cells called 'mucosal-associated invariant
T cells'(MAIT cells) has captured the attention of immunologists and clinicians due to their …
T cells'(MAIT cells) has captured the attention of immunologists and clinicians due to their …
Understanding human mast cells: lesson from therapies for allergic and non-allergic diseases
Mast cells have crucial roles in allergic and other inflammatory diseases. Preclinical
approaches provide circumstantial evidence for mast cell involvement in many diseases, but …
approaches provide circumstantial evidence for mast cell involvement in many diseases, but …
Mucosal-associated invariant T cells and disease
A Toubal, I Nel, S Lotersztajn, A Lehuen - Nature Reviews Immunology, 2019 - nature.com
Mucosal-associated invariant T (MAIT) cells are unique innate-like T cells that bridge innate
and adaptive immunity. They are activated by conserved bacterial ligands derived from …
and adaptive immunity. They are activated by conserved bacterial ligands derived from …
Mechanisms of immune regulation in allergic diseases: the role of regulatory T and B cells
O Palomares, M Akdis, M Martín‐Fontecha… - Immunological …, 2017 - Wiley Online Library
Allergy is a major public health problem with a high socio‐economic impact. The number of
allergic patients is expected to reach to four billion within two decades when the World's …
allergic patients is expected to reach to four billion within two decades when the World's …
Mast cells and their progenitors in allergic asthma
E Méndez-Enríquez, J Hallgren - Frontiers in immunology, 2019 - frontiersin.org
Mast cells and their mediators have been implicated in the pathogenesis of asthma and
allergy for decades. Allergic asthma is a complex chronic lung disease in which several …
allergy for decades. Allergic asthma is a complex chronic lung disease in which several …
Asthma phenotypes and IgE responses
A Froidure, J Mouthuy, SR Durham… - European …, 2016 - Eur Respiratory Soc
The discovery of IgE represented a major breakthrough in allergy and asthma research,
whereas the clinical interest given to IgE in asthma has been blurred until the arrival of anti …
whereas the clinical interest given to IgE in asthma has been blurred until the arrival of anti …
MAIT cell activation and functions
TSC Hinks, XW Zhang - Frontiers in immunology, 2020 - frontiersin.org
Mucosal associated invariant T (MAIT) cells are striking in their abundance and their strict
conservation across 150 million years of mammalian evolution, implying they must fulfill …
conservation across 150 million years of mammalian evolution, implying they must fulfill …
Interleukins (from IL-1 to IL-38), interferons, transforming growth factor β, and TNF-α: Receptors, functions, and roles in diseases
There have been extensive developments on cellular and molecular mechanisms of
immune regulation in allergy, asthma, autoimmune diseases, tumor development, organ …
immune regulation in allergy, asthma, autoimmune diseases, tumor development, organ …
[HTML][HTML] Activation and in vivo evolution of the MAIT cell transcriptome in mice and humans reveals tissue repair functionality
TSC Hinks, E Marchi, M Jabeen, M Olshansky… - Cell reports, 2019 - cell.com
Mucosal-associated invariant T (MAIT) cells are MR1-restricted innate-like T cells conserved
across mammalian species, including mice and humans. By sequencing RNA from sorted …
across mammalian species, including mice and humans. By sequencing RNA from sorted …
[HTML][HTML] Th2 responses: T helper 2 cells in asthma
Allergic asthma is among the most common immune-mediated diseases across the world,
and type 2 immune responses are thought to be central to pathogenesis. The importance of …
and type 2 immune responses are thought to be central to pathogenesis. The importance of …