There is an art and science to performing mouse anesthesia, which is a significant
component to animal research. Frequently, anesthesia is one vital step of many over the …

Cisplatin is one of the most widely used chemotherapeutic drugs in the treatment of a wide
range of pediatric and adult malignances. However, it has various side effects which limit its …

The success of base editors for the study and treatment of genetic diseases depends on the
ability to deliver them in vivo to the relevant cell types. Delivery via adeno-associated viruses …

Companion diagnostics (CDx) are powerful tests that can provide physicians with crucial
biomarker information that can improve treatment outcomes by matching therapies to …

Chronic inflammation is associated with normal and pathological ageing. Here we show that
chronic, progressive low-grade inflammation induced by knockout of the nfkb1 subunit of the …

Manufacturing autologous chimeric antigen receptor (CAR) T cell therapeutics is complex,
and many patients experience treatment delays or cannot be treated at all. Although current …

Rational design of chimeric antigen receptor T (CAR-T) cells based on the recognition of
antigenic epitopes capable of evoking the most potent CAR activation is an important …

Animal experiments remain essential to understand the fundamental mechanisms
underpinning malignancy and to discover improved methods to prevent, diagnose and treat …

Mesoporous silica nanoparticles (MSNs) are a promising material for drug delivery. In this
Full Paper, MSNs are first shown to be well tolerated, as demonstrated by serological …

Pathological growth of cardiomyocytes (hypertrophy) is a major determinant for the
development of heart failure, one of the leading medical causes of mortality worldwide. Here …