Mood disorders such as depression and anxiety are frequently observed in patients
suffering from chronic pain. Over time, different tests and models have been developed in …

Major depressive disorder (MDD) is a heritable neuropsychiatric disease associated with
severe changes at cellular and molecular levels. Its diagnosis mainly relies on the …

Adult hippocampal neurogenesis is increased by antidepressants, and is required for some
of their behavioral effects. However, it remains unclear whether expanding the population of …

Recent clinical studies demonstrate that serum levels of brain-derived neurotrophic factor
(BDNF) are significantly decreased in patients with major depressive disorder (MDD) and …

Major depression is a complex psychiatric disorder characterized by affective, cognitive, and
physiological impairments that lead to maladaptive behavior. The high lifetime prevalence of …

Zebrafish (Danio rerio) have emerged as a promising model organism to study
development, toxicology, pharmacology, and neuroscience, among other areas. Despite the …

Defining anxiety-and depressive-like states in mice (emotionality) is best characterized by
the use of complementary tests, leading sometimes to puzzling discrepancies and lack of …

Abstract Rationale Serotonin reuptake inhibitors (SSRIs) are effective in treating depression.
Given the existence of different families and subtypes of 5-HT receptors, multiple 5-HT …

Major depressive disorder is a debilitating disease. Unfortunately, treatment with
antidepressants (ADs) has limited therapeutic efficacy since resistance to AD is common …

Thymol, a bioactive monoterpene isolated from Thymus vulgaris, has displayed inspiring
neuroprotective properties. The present study was designed to evaluate the antidepressant …