Current treatments of spinal muscular atrophy in adults
P Cintas - Revue Neurologique, 2023 - Elsevier
Spinal muscular atrophy (SMA) is a rare autosomal recessive neuromuscular disorder
related to motor neuron degeneration. SMA patients present generally severe muscular …
related to motor neuron degeneration. SMA patients present generally severe muscular …
Ultrasound-guided interlaminar approach for nusinersen administration in patients with spinal muscular atrophy with spinal fusion or severe scoliosis
C Wei, Z Liang, Y Wu, S Liu, J Qiu, L Meng, C Li… - Orphanet Journal of …, 2023 - Springer
Background Intrathecal injection of medications can be challenging in spinal muscular
atrophy (SMA) patients with severe scoliosis or after spine surgery. Here we report our …
atrophy (SMA) patients with severe scoliosis or after spine surgery. Here we report our …
A systematic review of procedural complications from transforaminal lumbar puncture for intrathecal nusinersen administration in patients with spinal muscular atrophy
A Grayev, M Schoepp, A Kuner - American Journal of …, 2021 - Am Soc Neuroradiology
BACKGROUND: Spinal muscular atrophy is a progressive neurodegenerative disorder that
can be treated with intrathecal antisense oligonucleotide therapy (nusinersen). However …
can be treated with intrathecal antisense oligonucleotide therapy (nusinersen). However …
Unilateral interlaminar fenestration on the convex side provides a reliable access for intrathecal administration of nusinersen in spinal muscular atrophy: a …
Z Wang, E Feng, Y Jiao, J Zhao, X Chen… - Orphanet Journal of …, 2023 - Springer
Background As the first gene therapy for spinal muscular atrophy (SMA), nusinersen is
supposed to be administrated via intrathecal injection regularly for a lifetime. However, for …
supposed to be administrated via intrathecal injection regularly for a lifetime. However, for …
A horizontal and perpendicular interlaminar approach for intrathecal nusinersen injection in patients with spinal muscular atrophy and scoliosis: an observational …
C Huang, Y Zhang, DA Diedrich, J Li, W Luo… - Orphanet Journal of …, 2024 - Springer
Background Lumbar puncture is challenging for patients with scoliosis. Previous ultrasound-
assisted techniques for lumbar puncture used the angle of the probe as the needle …
assisted techniques for lumbar puncture used the angle of the probe as the needle …
Pediatric SMA patients with complex spinal anatomy: Implementation and evaluation of a decision-tree algorithm for administration of nusinersen
L Carrera-García, J Muchart, JJ Lazaro… - European Journal of …, 2021 - Elsevier
The approval of nusinersen for the treatment of spinal muscular atrophy (SMA) has
significantly changed the natural history of the disease. Nevertheless, scoliosis secondary to …
significantly changed the natural history of the disease. Nevertheless, scoliosis secondary to …
[HTML][HTML] Intrathecal administration of nusinersen using the ommaya reservoir in an adult with 5q-related spinal muscular atrophy type 1 and severe spinal deformity
V Papaliagkas, N Foroglou, P Toulios… - Case Reports in …, 2022 - karger.com
Spinal muscular atrophy (SMA) is a hereditary neuromuscular disorder, typically caused by
survival motor neuron 1 (SMN1) gene deletion in chromosome 5q resulting in loss of SMN …
survival motor neuron 1 (SMN1) gene deletion in chromosome 5q resulting in loss of SMN …
Posterior spinal correction and fusion surgery in patients with spinal muscular atrophy-associated scoliosis for whom treatment with nusinersen was planned
S Machida, M Miyagi, W Saito, A Matsui… - Spine Surgery and …, 2021 - jstage.jst.go.jp
Introduction: Spinal muscular atrophy (SMA) is defined as a neuromuscular disorder
induced by progressive weakness of the skeletal muscle and is usually accompanied by …
induced by progressive weakness of the skeletal muscle and is usually accompanied by …
Lumbar Transforaminal Injections of Nusinersen in Spinal Muscular Atrophy Patients
EJ Monroe - Neuroimaging Clinics, 2025 - neuroimaging.theclinics.com
Background Spinal muscular atrophy (SMA) is a rare and debilitating genetic disorder
resulting from deficiency in the survival motor neuron 1 (SMN1) gene, characterized by the …
resulting from deficiency in the survival motor neuron 1 (SMN1) gene, characterized by the …
Modified nusinersen intrathecal injection method: inclusion of a septal needle-free closed infusion connector
Y Zhang, K Zheng, C Liang, R Zheng, J Chen… - Frontiers in …, 2023 - frontiersin.org
Objective Nusinersen, an extremely expensive biologic drug (around 100,000 US $ per
dose) that needs to be administered intrathecally, is approved for the treatment of 5q-spinal …
dose) that needs to be administered intrathecally, is approved for the treatment of 5q-spinal …