Hypertension is a global public health issue and the leading cause of premature death in
humans. Despite more than a century of research, hypertension remains difficult to cure due …

Interleukin 11 (IL11) is an elusive member of the IL6 family of cytokines. While initially
thought to be a haematopoietic and cytoprotective factor, more recent data show instead that …

Interleukin 11 (IL11) is upregulated in inflammatory conditions, where it is mostly believed to
have anti-inflammatory activity. However, recent studies suggest instead that IL11 promotes …

Background Visceral adipose tissue in individuals with obesity is an independent
cardiovascular risk indicator. However, it remains unclear whether adipose tissue influences …

Marfan syndrome (MFS, OMIM: 154700) is a heritable multisystemic disease characterized
by a wide range of clinical manifestations. The underlying molecular defect is caused by …

Fibrillin-1 (FBN1) is a large, cysteine-rich, calcium binding extracellular matrix glycoprotein
encoded by FBN1 gene. It serves as a structural component of microfibrils and provides …

Background: Marfan Syndrome (MFS) is an inherited connective tissue disorder caused by
mutations in the FBN1 (fibrillin-1) gene. Lung abnormalities are common in MFS, but their …

Abstract Interleukin (IL-) 11, an IL-6 family cytokine, has pivotal roles in autoimmune
diseases, fibrotic complications, and solid cancers. Despite intense therapeutic targeting …

To improve the current treatment for vascular diseases, such as vascular grafts, intravascular
stents, and balloon angioplasty intervention, the evaluation of the native blood vessel …

Aortic aneurysms, including thoracic aortic aneurysms and abdominal aortic aneurysms, are
life-threatening macrovascular diseases with high mortality. The already known key …