Epidemiologic studies, including prospective birth cohort investigations, have implicated
maternal immune activation in the etiology of neuropsychiatric disorders. Maternal infectious …

Over the past decade, many studies have indicated that adolescence is a critical period of
brain development and maturation. The refinement and maturation of the central nervous …

Mutations in SHANK3 and large duplications of the region spanning SHANK3 both cause a
spectrum of neuropsychiatric disorders, indicating that proper SHANK3 dosage is critical for …

Prepulse inhibition (PPI) is a robust operational measure of sensorimotor gating. In
schizophrenic patients PPI is deficient. The aim of our review was to investigate the state of …

Introduction Under specific conditions, a weak lead stimulus, or “prepulse”, can inhibit the
startling effects of a subsequent intense abrupt stimulus. This startle-inhibiting effect of the …

BACKGROUND: The Oxford-Liverpool Inventory of Feelings and Experiences (O-LIFE) was
introduced in 1995 as a four-scale questionnaire for measuring psychosis-proneness …

Several converging lines of evidence suggest that the anterior cingulate cortex (ACC) is
selectively involved in error detection or evaluation of poor performance. Here we challenge …

Schizophrenia represents a pervasive deficit in brain function, leading to hallucinations and
delusions, social withdrawal and a decline in cognitive performance. As the underlying …

Lithium is used as treatment for bipolar disorder with particular efficacy in the treatment of
mania. Lithium inhibits glycogen synthase kinase 3β (GSK-3β) directly or indirectly via …

Almost 25 years after the first report that glutamate can activate receptors coupled to
heterotrimeric G-proteins, tremendous progress has been made in the field of metabotropic …