Molecular features and gene expression signature of metastatic colorectal cancer
M Poturnajova, T Furielova, S Balintova… - Oncology …, 2021 - spandidos-publications.com
Uncontrollable metastatic outgrowth process is the leading cause of mortality worldwide,
even in the case of colorectal cancer. Colorectal cancer (CRC) accounts for approximately …
even in the case of colorectal cancer. Colorectal cancer (CRC) accounts for approximately …
Overcoming therapy resistance in colon cancer by drug repurposing
Simple Summary Despite improvements in standardized screening methods and the
development of promising therapies for colorectal cancer (CRC), survival rates are still low …
development of promising therapies for colorectal cancer (CRC), survival rates are still low …
Statin associated lower cancer risk and related mortality in patients with heart failure
Aims Patients with heart failure (HF) have an increased risk of incident cancer. Data relating
to the association of statin use with cancer risk and cancer-related mortality among patients …
to the association of statin use with cancer risk and cancer-related mortality among patients …
MACC1 promotes pancreatic cancer metastasis by interacting with the EMT regulator SNAI1
X Zhang, Y Luo, Y Cen, X Qiu, J Li, M Jie, S Yang… - Cell Death & …, 2022 - nature.com
Metastasis is the dominant cause of cancer-related mortality. Metastasis-associated with
colon cancer protein 1 (MACC1) has been proven to play a critical role in cancer metastasis …
colon cancer protein 1 (MACC1) has been proven to play a critical role in cancer metastasis …
The low affinity neurotrophin receptor CD271 regulates phenotype switching in melanoma
G Restivo, J Diener, PF Cheng, G Kiowski… - Nature …, 2017 - nature.com
Cutaneous melanoma represents the most fatal skin cancer due to its high metastatic
capacity. According to the “phenotype switching” model, the aggressive nature of melanoma …
capacity. According to the “phenotype switching” model, the aggressive nature of melanoma …
Combinatorial treatment with statins and niclosamide prevents CRC dissemination by unhinging the MACC1-β-catenin-S100A4 axis of metastasis
B Kortüm, H Radhakrishnan, F Zincke, C Sachse… - Oncogene, 2022 - nature.com
Colorectal cancer (CRC) is the second-most common malignant disease worldwide, and
metastasis is the main culprit of CRC-related death. Metachronous metastases remain to be …
metastasis is the main culprit of CRC-related death. Metachronous metastases remain to be …
Statin uses and mortality in colorectal cancer patients: an updated systematic review and meta‐analysis
Y Li, X He, Y Ding, H Chen, L Sun - Cancer medicine, 2019 - Wiley Online Library
Background Colorectal cancer (CRC) remains one of the most common types of cancer and
a leading cause of death worldwide. Previous studies indicated that statins may have a …
a leading cause of death worldwide. Previous studies indicated that statins may have a …
MACC1—The first decade of a key metastasis molecule from gene discovery to clinical translation
H Radhakrishnan, W Walther, F Zincke… - Cancer and Metastasis …, 2018 - Springer
Deciphering the paths to metastasis and identifying key molecules driving this process is
one important issue for understanding and treatment of cancer. Such a key driver molecule …
one important issue for understanding and treatment of cancer. Such a key driver molecule …
Small-molecule drugs of colorectal cancer: Current status and future directions
Y Yang, P Liu, M Zhou, L Yin, M Wang, T Liu… - … et Biophysica Acta (BBA …, 2024 - Elsevier
Colorectal cancer (CRC) is the third most commonly diagnosed cancer and the world's
fourth most deadly cancer. CRC, as a genetic susceptible disease, faces significant …
fourth most deadly cancer. CRC, as a genetic susceptible disease, faces significant …
Natural small molecules in gastrointestinal tract and associated cancers: molecular insights and targeted therapies
F Islam, S Mitra, TB Emran, Z Khan, N Nath, R Das… - Molecules, 2022 - mdpi.com
Gastric cancer is one of the most common cancers of the gastrointestinal tract. Although
surgery is the primary treatment, serious maladies that dissipate to other parts of the body …
surgery is the primary treatment, serious maladies that dissipate to other parts of the body …