Molecular features and gene expression signature of metastatic colorectal cancer

M Poturnajova, T Furielova, S Balintova… - Oncology …, 2021 - spandidos-publications.com
Uncontrollable metastatic outgrowth process is the leading cause of mortality worldwide,
even in the case of colorectal cancer. Colorectal cancer (CRC) accounts for approximately …

Overcoming therapy resistance in colon cancer by drug repurposing

T El Zarif, M Yibirin, D De Oliveira-Gomes… - Cancers, 2022 - mdpi.com
Simple Summary Despite improvements in standardized screening methods and the
development of promising therapies for colorectal cancer (CRC), survival rates are still low …

Statin associated lower cancer risk and related mortality in patients with heart failure

QW Ren, SY Yu, THK Teng, X Li… - European heart …, 2021 - academic.oup.com
Aims Patients with heart failure (HF) have an increased risk of incident cancer. Data relating
to the association of statin use with cancer risk and cancer-related mortality among patients …

MACC1 promotes pancreatic cancer metastasis by interacting with the EMT regulator SNAI1

X Zhang, Y Luo, Y Cen, X Qiu, J Li, M Jie, S Yang… - Cell Death & …, 2022 - nature.com
Metastasis is the dominant cause of cancer-related mortality. Metastasis-associated with
colon cancer protein 1 (MACC1) has been proven to play a critical role in cancer metastasis …

The low affinity neurotrophin receptor CD271 regulates phenotype switching in melanoma

G Restivo, J Diener, PF Cheng, G Kiowski… - Nature …, 2017 - nature.com
Cutaneous melanoma represents the most fatal skin cancer due to its high metastatic
capacity. According to the “phenotype switching” model, the aggressive nature of melanoma …

Combinatorial treatment with statins and niclosamide prevents CRC dissemination by unhinging the MACC1-β-catenin-S100A4 axis of metastasis

B Kortüm, H Radhakrishnan, F Zincke, C Sachse… - Oncogene, 2022 - nature.com
Colorectal cancer (CRC) is the second-most common malignant disease worldwide, and
metastasis is the main culprit of CRC-related death. Metachronous metastases remain to be …

Statin uses and mortality in colorectal cancer patients: an updated systematic review and meta‐analysis

Y Li, X He, Y Ding, H Chen, L Sun - Cancer medicine, 2019 - Wiley Online Library
Background Colorectal cancer (CRC) remains one of the most common types of cancer and
a leading cause of death worldwide. Previous studies indicated that statins may have a …

MACC1—The first decade of a key metastasis molecule from gene discovery to clinical translation

H Radhakrishnan, W Walther, F Zincke… - Cancer and Metastasis …, 2018 - Springer
Deciphering the paths to metastasis and identifying key molecules driving this process is
one important issue for understanding and treatment of cancer. Such a key driver molecule …

Small-molecule drugs of colorectal cancer: Current status and future directions

Y Yang, P Liu, M Zhou, L Yin, M Wang, T Liu… - … et Biophysica Acta (BBA …, 2024 - Elsevier
Colorectal cancer (CRC) is the third most commonly diagnosed cancer and the world's
fourth most deadly cancer. CRC, as a genetic susceptible disease, faces significant …

Natural small molecules in gastrointestinal tract and associated cancers: molecular insights and targeted therapies

F Islam, S Mitra, TB Emran, Z Khan, N Nath, R Das… - Molecules, 2022 - mdpi.com
Gastric cancer is one of the most common cancers of the gastrointestinal tract. Although
surgery is the primary treatment, serious maladies that dissipate to other parts of the body …