Genotypic resistance testing of HIV-1 DNA in peripheral blood mononuclear cells
C Chu, D Armenia, C Walworth… - Clinical Microbiology …, 2022 - Am Soc Microbiol
SUMMARY HIV-1 DNA exists in nonintegrated linear and circular episomal forms and as
integrated proviruses. In patients with plasma viremia, most peripheral blood mononuclear …
integrated proviruses. In patients with plasma viremia, most peripheral blood mononuclear …
Early intervention with 3BNC117 and romidepsin at antiretroviral treatment initiation in people with HIV-1: a phase 1b/2a, randomized trial
JD Gunst, MH Pahus, M Rosás-Umbert, IN Lu… - Nature medicine, 2022 - nature.com
Attempts to reduce the human immunodeficiency virus type 1 (HIV-1) reservoir and induce
antiretroviral therapy (ART)-free virologic control have largely been unsuccessful. In this …
antiretroviral therapy (ART)-free virologic control have largely been unsuccessful. In this …
Consequences of HIV infection in the bone marrow niche
CL Herd, J Mellet, T Mashingaidze, C Durandt… - Frontiers in …, 2023 - frontiersin.org
Dysregulation of the bone marrow niche resulting from the direct and indirect effects of HIV
infection contributes to haematological abnormalities observed in HIV patients. The bone …
infection contributes to haematological abnormalities observed in HIV patients. The bone …
The replication-competent HIV-1 latent reservoir is primarily established near the time of therapy initiation
MR Abrahams, SB Joseph, N Garrett, L Tyers… - Science translational …, 2019 - science.org
Although antiretroviral therapy (ART) is highly effective at suppressing HIV-1 replication, the
virus persists as a latent reservoir in resting CD4+ T cells during therapy. This reservoir …
virus persists as a latent reservoir in resting CD4+ T cells during therapy. This reservoir …
Antiretroviral therapy reveals triphasic decay of intact SIV genomes and persistence of ancestral variants
The decay kinetics of HIV-1-infected cells are critical to understand virus persistence. We
evaluated the frequency of simian immunodeficiency virus (SIV)-infected cells for 4 years of …
evaluated the frequency of simian immunodeficiency virus (SIV)-infected cells for 4 years of …
The replication-competent HIV reservoir is a genetically restricted, younger subset of the overall pool of HIV proviruses persisting during therapy, which is highly …
Within-host HIV populations continually diversify during untreated infection, and this diversity
persists within infected cell reservoirs during antiretroviral therapy (ART). Achieving a better …
persists within infected cell reservoirs during antiretroviral therapy (ART). Achieving a better …
Dynamics of HIV DNA reservoir seeding in a cohort of superinfected Kenyan women
A reservoir of HIV-infected cells that persists despite suppressive antiretroviral therapy (ART)
is the source of viral rebound upon ART cessation and the major barrier to a cure …
is the source of viral rebound upon ART cessation and the major barrier to a cure …
[HTML][HTML] HIV-1 variants are archived throughout infection and persist in the reservoir
The HIV-1 reservoir consists of latently infected cells that persist despite antiretroviral
therapy (ART). Elucidating the proviral genetic composition of the reservoir, particularly in …
therapy (ART). Elucidating the proviral genetic composition of the reservoir, particularly in …
Analysis of the effect of HDAC inhibitors on the formation of the HIV reservoir
L Ling, M Kim, A Soper, M Kovarova, RA Spagnuolo… - Mbio, 2024 - journals.asm.org
The HIV reservoir is more dynamic than previously thought with around 70% of the latent
reservoir originating from viruses circulating within 1 year of the initiation of antiretroviral …
reservoir originating from viruses circulating within 1 year of the initiation of antiretroviral …
Potential impact of the antirheumatic agent auranofin on proviral HIV-1 DNA in individuals under intensified antiretroviral therapy: Results from a randomised clinical …
Antiretroviral therapy (ART) is typically composed of a combination of three antiretroviral
drugs and is the treatment of choice for people with human immunodeficiency virus type …
drugs and is the treatment of choice for people with human immunodeficiency virus type …