Brain vulnerability and viability after ischaemia

SG Daniele, G Trummer, KA Hossmann… - Nature Reviews …, 2021 - nature.com
The susceptibility of the brain to ischaemic injury dramatically limits its viability following
interruptions in blood flow. However, data from studies of dissociated cells, tissue …

Neuroprotective properties of xenon

M Maze, T Laitio - Molecular neurobiology, 2020 - Springer
Xenon is a rare noble gas that was introduced into clinical practice more than 70 years ago.
Xenon's clinical properties are predicated by its ability to fit into preformed cavities of …

Noble gas and neuroprotection: From bench to bedside

H Yin, Z Chen, H Zhao, H Huang, W Liu - Frontiers in Pharmacology, 2022 - frontiersin.org
In recent years, inert gases such as helium, argon, and xenon have gained considerable
attention for their medical value. Noble gases present an intriguing scientific paradox …

Pharmacological approach for neuroprotection after cardiac arrest—a narrative review of current therapies and future neuroprotective cocktail

RC Choudhary, M Shoaib, S Sohnen… - Frontiers in …, 2021 - frontiersin.org
Cardiac arrest (CA) results in global ischemia-reperfusion injury damaging tissues in the
whole body. The landscape of therapeutic interventions in resuscitation medicine has …

Noble gases therapy in cardiocerebrovascular diseases: the novel stars?

J Zhang, W Liu, M Bi, J Xu, H Yang… - Frontiers in …, 2022 - frontiersin.org
Cardiocerebrovascular diseases (CCVDs) are the leading cause of death worldwide;
therefore, to deeply explore the pathogenesis of CCVDs and to find the cheap and efficient …

Non-pharmaceutical therapies for stroke: mechanisms and clinical implications

F Chen, Z Qi, Y Luo, T Hinchliffe, G Ding, Y Xia… - Progress in …, 2014 - Elsevier
Stroke is deemed a worldwide leading cause of neurological disability and death, however,
there is currently no promising pharmacotherapy for acute ischemic stroke aside from …

[HTML][HTML] Neuroprotection by the noble gases argon and xenon as treatments for acquired brain injury: a preclinical systematic review and meta-analysis

M Liang, F Ahmad, R Dickinson - British Journal of Anaesthesia, 2022 - Elsevier
Background The noble gases argon and xenon are potential novel neuroprotective
treatments for acquired brain injuries. Xenon has already undergone early-stage clinical …

Update of the organoprotective properties of xenon and argon: from bench to beside

R Anna, R Rolf, C Mark - Intensive care medicine experimental, 2020 - Springer
The growth of the elderly population has led to an increase in patients with myocardial
infarction and stroke (Wajngarten and Silva, Eur Cardiol 14: 111–115, 2019). Patients …

Argon reduces neurohistopathological damage and preserves functional recovery after cardiac arrest in rats

A Brücken, A Cizen, C Fera, A Meinhardt… - British Journal of …, 2013 - academic.oup.com
Background Xenon has profound neuroprotective effects after neurological injury and is
currently undergoing phase 2 clinical trials in cardiac arrest patients. However, xenon is very …

Feasibility and cardiac safety of inhaled xenon in combination with therapeutic hypothermia following out-of-hospital cardiac arrest

OJ Arola, RM Laitio, RO Roine, J Grönlund… - Critical care …, 2013 - journals.lww.com
Objectives: Preclinical studies reveal the neuroprotective properties of xenon, especially
when combined with hypothermia. The purpose of this study was to investigate the feasibility …