Hepatocellular carcinoma (HCC) is an aggressive human cancer with increasing incidence
worldwide. Multiple efforts have been made to explore pharmaceutical therapies to treat …

Hypoxia, low oxygen (O2) level, is a hallmark of solid cancers, especially hepatocellular
carcinoma (HCC), one of the most common and fatal cancers worldwide. Hypoxia …

Reversible, spatial, and temporal regulation of metabolic reprogramming and epigenetic
homeostasis are prominent hallmarks of carcinogenesis. Cancer cells reprogram their …

Serine synthesis is crucial for tumor growth and survival, but its regulatory mechanism in
cancer remains elusive. Here, using integrative metabolomics and transcriptomics analyses …

Serine metabolism promotes tumor oncogenesis and regulates immune cell functions, but
whether it also contributes to antiviral innate immunity is unknown. Here, we demonstrate …

Hepatocellular carcinoma (HCC) accounts for over 80% of liver cancer cases and is highly
malignant, recurrent, drug‐resistant, and often diagnosed in the advanced stage. It is clear …

Molecular heterogeneity of hepatobiliary tumor including intertumoral and intratumoral
disparity always leads to drug resistance. Here, seven hepatobiliary tumor organoids are …

Background & Aims Obesity is an independent risk factor for malignancies, including
hepatocellular carcinoma (HCC). However, it remains unknown whether maternal obesity …

Increased aerobic glycolysis is a hallmark of cancer metabolism. How cancer cells
coordinate glucose metabolism with extracellular glucose levels remains largely unknown …

Abstract Rationale: Ischemia-reperfusion (IR) induced acute kidney injury (AKI) causes
serious clinical problems associated with high morbidity and mortality. Mecp2 is a methyl …