Conspectus This Account summarizes the progress in protein–calixarene complexation,
tracing the developments from binary recognition to the glue activity of calixarenes and …

The filamentous fungus Penicillium chrysogenum Q176 secretes the antimicrobial proteins
(AMPs) PAF and PAFB, which share a compact disulfide-bond mediated, β-fold structure …

Antifungal proteins of fungal origin (AFPs) are small, secreted, cationic, and cysteine-rich
proteins. Filamentous fungi encode a wide repertoire of AFPs belonging to different …

Competition is one of the fundamental driving forces of natural selection. Beauveria
bassiana is a soil and plant phylloplane/root fungus capable of parasitizing insect hosts. Soil …

Synthetic macrocycles such as calixarenes and cucurbiturils are increasingly applied as
mediators of protein assembly and crystallization. The macrocycle can facilitate assembly by …

Background Small, cysteine-rich and cationic antifungal proteins (APs) from filamentous
ascomycetes, such as NFAP from Neosartorya fischeri and PAF from Penicillium …

Small, cysteine-rich and cationic proteins with antimicrobial activity are produced by diverse
organisms of all kingdoms and represent promising molecules for drug development. The …

Phosphate is an essential anion in the human body, comprising approximately 1% of the
total body weight, and playing a vital role in metabolism, cell membranes, and bone …

Filamentous fungi encode distinct antifungal proteins (AFPs) that offer great potential to
develop new antifungals. Fungi are considered immune to their own AFPs as occurs in …

Highlights•Considering conformational flexibility improves structure-based drug
design.•Computational simulations provide mechanistic insights in biological …