Amino assets: how amino acids support immunity
Amino acids are fundamental building blocks supporting life. Their role in protein synthesis
is well defined, but they contribute to a host of other intracellular metabolic pathways …
is well defined, but they contribute to a host of other intracellular metabolic pathways …
Targeting SLC1A5 and SLC3A2/SLC7A5 as a potential strategy to strengthen anti-tumor immunity in the tumor microenvironment
Cancer cells are metabolically vigorous and are superior in the uptake of nutrients and in the
release of the tumor microenvironment (TME)-specific metabolites. They create an acidic …
release of the tumor microenvironment (TME)-specific metabolites. They create an acidic …
Control of amino-acid transport by antigen receptors coordinates the metabolic reprogramming essential for T cell differentiation
LV Sinclair, J Rolf, E Emslie, YB Shi, PM Taylor… - Nature …, 2013 - nature.com
T lymphocytes must regulate nutrient uptake to meet the metabolic demands of an immune
response. Here we show that the intracellular supply of large neutral amino acids (LNAAs) in …
response. Here we show that the intracellular supply of large neutral amino acids (LNAAs) in …
Metabolic regulation of hepatitis B immunopathology by myeloid-derived suppressor cells
Infection with hepatitis B virus (HBV) results in disparate degrees of tissue injury: the virus
can either replicate without pathological consequences or trigger immune-mediated …
can either replicate without pathological consequences or trigger immune-mediated …
Amino-acid transporters in T-cell activation and differentiation
T-cell-mediated immune responses aim to protect mammals against cancers and infections,
and are also involved in the pathogenesis of various inflammatory or autoimmune diseases …
and are also involved in the pathogenesis of various inflammatory or autoimmune diseases …
CD98 at the crossroads of adaptive immunity and cancer
JM Cantor, MH Ginsberg - Journal of cell science, 2012 - journals.biologists.com
Adaptive immunity, a vertebrate specialization, adds memory and exquisite specificity to the
basic innate immune responses present in invertebrates while conserving metabolic …
basic innate immune responses present in invertebrates while conserving metabolic …
mTOR signaling, Tregs and immune modulation
NM Chapman, H Chi - Immunotherapy, 2014 - Taylor & Francis
Foxp3+ Tregs are central regulators of immune tolerance. As dysregulated Treg responses
contribute to disease pathogenesis, novel approaches to target the immunomodulatory …
contribute to disease pathogenesis, novel approaches to target the immunomodulatory …
Slc3a2 mediates branched-chain amino-acid-dependent maintenance of regulatory T cells
K Ikeda, M Kinoshita, H Kayama, S Nagamori… - Cell reports, 2017 - cell.com
Summary Foxp3+ regulatory T (Treg) cells, which suppress immune responses, are highly
proliferative in vivo. However, it remains unclear how the active replication of Treg cells is …
proliferative in vivo. However, it remains unclear how the active replication of Treg cells is …
[HTML][HTML] The role of branched chain amino acids metabolic disorders in tumorigenesis and progression
J Wang, W Wang, F Zhu, Q Duan - Biomedicine & Pharmacotherapy, 2022 - Elsevier
Branched-chain amino acids (BCAAs) are essential amino acids in human bodies. They
have complex metabolic pathways and various metabolites. Both BCAAs and its metabolites …
have complex metabolic pathways and various metabolites. Both BCAAs and its metabolites …
CD98 heavy chain as a prognostic biomarker and target for cancer treatment
P Xia, A Dubrovska - Frontiers in Oncology, 2023 - frontiersin.org
The SLC3A2 gene encodes for a cell-surface transmembrane protein CD98hc (4F2).
CD98hc serves as a chaperone for LAT1 (SLC7A5), LAT2 (SLC7A8), y+ LAT1 (SLC7A7), y+ …
CD98hc serves as a chaperone for LAT1 (SLC7A5), LAT2 (SLC7A8), y+ LAT1 (SLC7A7), y+ …