Epigenetic control of human endogenous retrovirus expression: focus on regulation of long-terminal repeats (LTRs)
TP Hurst, G Magiorkinis - Viruses, 2017 - mdpi.com
Transposable elements, including endogenous retroviruses (ERVs), comprise almost 45%
of the human genome. This could represent a significant pathogenic burden but it is …
of the human genome. This could represent a significant pathogenic burden but it is …
Role of viruses in human evolution
LM Van Blerkom - … Anthropology: The Official Publication of the …, 2003 - Wiley Online Library
The study of viral molecular genetics has produced a considerable body of research into the
sequences and phylogenetic relationships of human and animal viruses. A review of this …
sequences and phylogenetic relationships of human and animal viruses. A review of this …
Intrinsic retroviral reactivation in human preimplantation embryos and pluripotent cells
Endogenous retroviruses (ERVs) are remnants of ancient retroviral infections, and comprise
nearly 8% of the human genome. The most recently acquired human ERV is HERVK (HML …
nearly 8% of the human genome. The most recently acquired human ERV is HERVK (HML …
Retroviral RNA identified in the cerebrospinal fluids and brains of individuals with schizophrenia
H Karlsson, S Bachmann, J Schröder… - Proceedings of the …, 2001 - National Acad Sciences
Schizophrenia is a serious brain disease of uncertain etiology. A role for retroviruses in the
etiopathogenesis of some cases of schizophrenia has been postulated on the basis of …
etiopathogenesis of some cases of schizophrenia has been postulated on the basis of …
CpG methylation directly regulates transcriptional activity of the human endogenous retrovirus family HERV-K (HML-2)
L Lavie, M Kitova, E Maldener, E Meese… - Journal of virology, 2005 - Am Soc Microbiol
ABSTRACT A significant proportion of the human genome consists of stably inherited
retroviral sequences. Most human endogenous retroviruses (HERVs) became defective over …
retroviral sequences. Most human endogenous retroviruses (HERVs) became defective over …
Molecular functions of human endogenous retroviruses in health and disease
M Suntsova, A Garazha, A Ivanova, D Kaminsky… - Cellular and Molecular …, 2015 - Springer
Human endogenous retroviruses (HERVs) and related genetic elements form 504 distinct
families and occupy~ 8% of human genome. Recent success of high-throughput …
families and occupy~ 8% of human genome. Recent success of high-throughput …
Transactivation of human endogenous retroviruses by tumor viruses and their functions in virus-associated malignancies
Human endogenous retroviruses (HERVs), viral-associated sequences, are normal
components of the human genome and account for 8–9% of our genome. These original …
components of the human genome and account for 8–9% of our genome. These original …
[HTML][HTML] Solitary HERV-K LTRs possess bi-directional promoter activity and contain a negative regulatory element in the U5 region
AN Domansky, EP Kopantzev, EV Snezhkov… - FEBS letters, 2000 - Elsevier
Reporter gene analysis of HERV-K solitary long terminal repeats (LTRs) showed that they
retain detectable activity in human teratocarcinoma cells, and can direct the transcription in …
retain detectable activity in human teratocarcinoma cells, and can direct the transcription in …
Regulation of human endogenous retrovirus‐K expression in melanomas by CpG methylation
S Stengel, U Fiebig, R Kurth… - Genes, Chromosomes …, 2010 - Wiley Online Library
The overall prognosis of patients with advanced melanoma is poor due to the lack of
effective treatment. A key factor for successful therapy is an early detection of disease …
effective treatment. A key factor for successful therapy is an early detection of disease …
Implication of the env gene of the human endogenous retrovirus W family in the expression of BDNF and DRD3 and development of recent-onset schizophrenia
WJ Huang, S Li, YM Hu, H Yu, F Luo… - Schizophrenia …, 2011 - academic.oup.com
Objective: Retrovirus has been suggested as one of agents involved in the development of
schizophrenia. In the present study, we examined the role of the human endogenous …
schizophrenia. In the present study, we examined the role of the human endogenous …