GDF15 has recently gained scientific and translational prominence with the discovery that its
receptor is a GFRAL-RET heterodimer of which GFRAL is expressed solely in the hindbrain …

Over the past 10 years, the field of immunometabolism made great strides to unveil the
crucial role of intracellular metabolism in regulating immune cell function. Emerging insights …

Growth and differentiation factor 15 (GDF15) is an inflammation-associated hormone with
poorly defined biology. Here, we investigated the role of GDF15 in bacterial and viral …

An acute increase in the circulating concentration of glucocorticoid hormones is essential for
the survival of severe somatic stresses. Circulating concentrations of GDF15, a hormone that …

Trained immunity defines long-lasting adaptations of innate immunity based on
transcriptional and epigenetic modifications of myeloid cells and their bone marrow …

Nonsteroidal anti-inflammatory drugs (NSAIDs) inhibit cyclooxygenase (COX) enzymes and
are ubiquitously used for their anti-inflammatory properties. However, COX inhibition alone …

Misguided attack of immune systems on self-tissue or multifactorial uncontrolled
inflammation is capable of causing inflammatory diseases. Neutrophils play a critical role in …

Growth differentiation factor 15 (GDF-15) is a transforming growth factor (TGF)-β superfamily
cytokine that plays a central role in metabolism regulation. Produced in response to …

Abstract Growth differentiation factor 15 (GDF15), a member of the transforming growth
factor-beta superfamily, is expressed in several human organs. In particular, it is highly …

Nutrition is essential for supplying an organism with sufficient energy to maintain its bodily
functions. Apart from serving as an energy supply, the immunomodulatory effects of diet are …