Fundamental Aspects of Phase-Separated Biomolecular Condensates
Biomolecular condensates, formed through phase separation, are upending our
understanding in much of molecular, cell, and developmental biology. There is an urgent …
understanding in much of molecular, cell, and developmental biology. There is an urgent …
Theoretical and data-driven approaches for biomolecular condensates
Biomolecular condensation processes are increasingly recognized as a fundamental
mechanism that living cells use to organize biomolecules in time and space. These …
mechanism that living cells use to organize biomolecules in time and space. These …
Sequence-dependent material properties of biomolecular condensates and their relation to dilute phase conformations
D Sundaravadivelu Devarajan, J Wang… - Nature …, 2024 - nature.com
Material properties of phase-separated biomolecular condensates, enriched with disordered
proteins, dictate many cellular functions. Contrary to the progress made in understanding the …
proteins, dictate many cellular functions. Contrary to the progress made in understanding the …
Sequence-specific interactions determine viscoelasticity and ageing dynamics of protein condensates
Biomolecular condensates are viscoelastic materials. Here we investigate the determinants
of the sequence-encoded and age-dependent viscoelasticity of condensates formed by the …
of the sequence-encoded and age-dependent viscoelasticity of condensates formed by the …
Adenosine triphosphate mediates phase separation of disordered basic proteins by bridging intermolecular interaction networks
Adenosine triphosphate (ATP) is an abundant molecule with crucial cellular roles as the
energy currency and a building block of nucleic acids and for protein phosphorylation. Here …
energy currency and a building block of nucleic acids and for protein phosphorylation. Here …
Determinants of viscoelasticity and flow activation energy in biomolecular condensates
The form and function of biomolecular condensates are intimately linked to their material
properties. Here, we integrate microrheology with molecular simulations to dissect the …
properties. Here, we integrate microrheology with molecular simulations to dissect the …
[HTML][HTML] Sequence-dependent material properties of biomolecular condensates and their relation to dilute phase conformations
DS Devarajan, J Wang, B Szała-Mendyk… - Nature …, 2024 - ncbi.nlm.nih.gov
Material properties of phase-separated biomolecular condensates, enriched with disordered
proteins, dictate many cellular functions. Contrary to the progress made in understanding the …
proteins, dictate many cellular functions. Contrary to the progress made in understanding the …
[HTML][HTML] Amino acid-dependent phase equilibrium and material properties of tetrapeptide condensates
The rules of how amino acids dictate the physical properties of biomolecular condensates
are still incomplete. Here, we study condensates formed by tetrapeptides of the form …
are still incomplete. Here, we study condensates formed by tetrapeptides of the form …
[HTML][HTML] ATP mediates phase separation of disordered basic proteins by bridging intermolecular interaction networks
ATP is an abundant molecule with crucial cellular roles as the energy currency and a
building block of nucleic acids and for protein phosphorylation. Here we show that ATP …
building block of nucleic acids and for protein phosphorylation. Here we show that ATP …
[HTML][HTML] Amino Acid-Dependent Material Properties of Tetrapeptide Condensates
Condensates formed by intrinsically disordered proteins mediate a myriad of cellular
processes and are linked to pathological conditions including neurodegeneration. Rules of …
processes and are linked to pathological conditions including neurodegeneration. Rules of …