Anti-inflammatory drugs and herbs with special emphasis on herbal medicines for countering inflammatory diseases and disorders-a review

MI Yatoo, A Gopalakrishnan, A Saxena… - Recent patents on …, 2018 - benthamdirect.com
Background: Diseases with inflammatory etiopathology have increased in incidence in
recent times. Drugs used for therapeutic management of such inflammatory diseases are …

Multitargeted effects of vitexin and isovitexin on diabetes mellitus and its complications

IL Abdulai, SK Kwofie, WS Gbewonyo… - The Scientific World …, 2021 - Wiley Online Library
Background. Till date, there is no known antidote to cure diabetes mellitus despite the
discovery and development of diverse pharmacotherapeutic agents many years ago …

Gut-lymph-lung pathway mediates sepsis-induced acute lung injury

C Jin, J Chen, J Gu, W Zhang - Chinese Medical Journal, 2020 - mednexus.org
This review attempts to unveil the possible mechanisms underlying how gut lymph affects
lung and further gives rise to acute respiratory distress syndrome, as well as potential …

5-Lipoxygenase: its involvement in gastrointestinal malignancies

N Merchant, LVKS Bhaskar, S Momin, P Sujatha… - Critical Reviews in …, 2018 - Elsevier
Lipoxygenases (LOXs) are dioxygenases that catalyze the peroxidation of linoleic acid (LA)
or arachidonic acid (AA), in the presence of molecular oxygen. The existence of …

Biologically Active 2-Oxazolidinone Derivatives Beyond Antibacterial Activities

L Yuan, R Sheng, M Guan, Y Wang… - Current Medicinal …, 2023 - ingentaconnect.com
2-Oxazolidinone is well known as a pharmacophore for antibacterial agents represented by
two marketed medicines, Linezolid and Tedizolid. On the other hand, there are growing …

Characterization and antiinflammatory properties of fractionated pyroligneous acid from palm kernel shell

Z Rabiu, MAAM Hamzah, R Hasham… - … Science and Pollution …, 2021 - Springer
Pyroligneous acid (PA) obtained from slow pyrolysis of palm kernel shell (PKS) has high
total phenolic contents and exhibits various biological activities including antioxidant …

In silico investigations of some Cyperus rotundus compounds as potential anti-inflammatory inhibitors of 5-LO and LTA4H enzymes

F Fenanir, A Semmeq, Y Benguerba… - Journal of …, 2022 - Taylor & Francis
The present study aimed to experimentally identify the essential oil of Algerian Cyperus
rotundus L. and to model the interaction of some known anti-inflammatory molecules with …

Discovery of a novel 2, 5-dihydroxycinnamic acid-based 5-lipoxygenase inhibitor that induces apoptosis and may impair autophagic flux in RCC4 renal cancer cells

A Selka, JA Doiron, P Lyons, S Dastous… - European Journal of …, 2019 - Elsevier
Abstract The inhibition of 5-lipoxygenase (5-LO), the key enzyme for the biosynthesis of
leukotrienes (LTs), has generated increasing enthusiasm as anti-inflammatory and antitumor …

Discovery of pharmacological agents for triple-negative breast cancer (TNBC): molecular docking and molecular dynamic simulation studies on 5-lipoxygenase (5 …

S Kundu, SN - Journal of Biomolecular Structure and Dynamics, 2024 - Taylor & Francis
Global burden of breast cancer is expected to cross 26 million new cases by 2030. The term
'triple negative breast cancer'(TNBC) refers to lack of expression of hormone receptors (ER …

Lipoxygenase inhibitors as cancer chemopreventives: Discovery, recent developments and future perspectives

M Mahboubi-Rabbani, A Zarghi - Current Medicinal Chemistry, 2021 - ingentaconnect.com
Background: Leukotrienes (LTs) constitute a bioactive group of Polyunsaturated Fatty Acid
(PUFA) metabolites molded by the enzymatic activity of lipoxygenase (LO) and have a …