Neuroinflammation in psychiatric disorders: PET imaging and promising new targets
Neuroinflammation is a multifaceted physiological and pathophysiological response of the
brain to injury and disease. Given imaging findings of 18 kDa translocator protein (TSPO) …
brain to injury and disease. Given imaging findings of 18 kDa translocator protein (TSPO) …
[HTML][HTML] Inflammation-related functional and structural dysconnectivity as a pathway to psychopathology
Findings from numerous laboratories and across neuroimaging modalities have consistently
shown that exogenous administration of cytokines or inflammatory stimuli that induce …
shown that exogenous administration of cytokines or inflammatory stimuli that induce …
Augmentation therapy with minocycline in treatment-resistant depression patients with low-grade peripheral inflammation: results from a double-blind randomised …
MA Nettis, G Lombardo, C Hastings… - …, 2021 - nature.com
This study aimed to investigate the role of baseline levels of peripheral inflammation when
testing the efficacy of antidepressant augmentation with minocycline in patients with …
testing the efficacy of antidepressant augmentation with minocycline in patients with …
Sick for science: experimental endotoxemia as a translational tool to develop and test new therapies for inflammation-associated depression
J Lasselin, M Lekander, S Benson, M Schedlowski… - Molecular …, 2021 - nature.com
Depression is one of the global leading causes of disability, but treatments remain limited
and classical antidepressants were found to be ineffective in a substantial proportion of …
and classical antidepressants were found to be ineffective in a substantial proportion of …
[HTML][HTML] Choroid plexus enlargement is associated with neuroinflammation and reduction of blood brain barrier permeability in depression
Background Recent studies have shown that choroid plexuses (CP) may be involved in the
neuro-immune axes, playing a role in the interaction between the central and peripheral …
neuro-immune axes, playing a role in the interaction between the central and peripheral …
Increased serum peripheral C-reactive protein is associated with reduced brain barriers permeability of TSPO radioligands in healthy volunteers and depressed …
The relationship between peripheral and central immunity and how these ultimately may
cause depressed behaviour has been the focus of a number of imaging studies conducted …
cause depressed behaviour has been the focus of a number of imaging studies conducted …
Neuroinflammation and its association with cognition, neuronal markers and peripheral inflammation after chemotherapy for breast cancer
G Schroyen, J Blommaert, D van Weehaeghe, C Sleurs… - Cancers, 2021 - mdpi.com
Simple Summary Up to 70% of chemotherapy-treated patients experience problems with
memory and concentration, potentially caused by direct and indirect neurotoxicity, such as …
memory and concentration, potentially caused by direct and indirect neurotoxicity, such as …
Control of neuroinflammation through radiation-induced microglial changes
A Boyd, S Byrne, RJ Middleton, RB Banati, GJ Liu - Cells, 2021 - mdpi.com
Microglia, the innate immune cells of the central nervous system, play a pivotal role in the
modulation of neuroinflammation. Neuroinflammation has been implicated in many diseases …
modulation of neuroinflammation. Neuroinflammation has been implicated in many diseases …
[HTML][HTML] Sickness behaviour and depression: An updated model of peripheral-central immunity interactions
Current research into mood disorders indicates that circulating immune mediators
participating in the pathophysiology of chronic somatic disorders have potent influences on …
participating in the pathophysiology of chronic somatic disorders have potent influences on …
A few-shot U-Net deep learning model for lung cancer lesion segmentation via PET/CT imaging
Over the past few years, positron emission tomography/computed tomography (PET/CT)
imaging for computer-aided diagnosis has received increasing attention. Supervised deep …
imaging for computer-aided diagnosis has received increasing attention. Supervised deep …