[HTML][HTML] Mesenchymal stem cell-derived extracellular vesicles for immunomodulation and regeneration: a next generation therapeutic tool?

M Kou, L Huang, J Yang, Z Chiang, S Chen, J Liu… - Cell death & …, 2022 - nature.com
Mesenchymal stem cells (MSCs) can be widely isolated from various tissues including bone
marrow, umbilical cord, and adipose tissue, with the potential for self-renewal and …

[HTML][HTML] The exosome journey: from biogenesis to uptake and intracellular signalling

S Gurung, D Perocheau, L Touramanidou… - Cell Communication and …, 2021 - Springer
The use of exosomes in clinical settings is progressively becoming a reality, as clinical trials
testing exosomes for diagnostic and therapeutic applications are generating remarkable …

Exosome-mediated delivery of Cas9 ribonucleoprotein complexes for tissue-specific gene therapy of liver diseases

T Wan, J Zhong, Q Pan, T Zhou, Y Ping, X Liu - Science advances, 2022 - science.org
CRISPR-Cas9 gene editing has emerged as a powerful therapeutic technology, but the lack
of safe and efficient in vivo delivery systems, especially for tissue-specific vectors, limits its …

Pancreatic cancer-targeting exosomes for enhancing immunotherapy and reprogramming tumor microenvironment

W Zhou, Y Zhou, X Chen, T Ning, H Chen, Q Guo… - Biomaterials, 2021 - Elsevier
Immunotherapy has gained increasing focus in treating pancreatic ductal adenocarcinoma
(PDAC), since conventional therapies like chemotherapy could not provide satisfactory …

[HTML][HTML] Plant exosome-like nanovesicles: emerging therapeutics and drug delivery nanoplatforms

HA Dad, TW Gu, AQ Zhu, LQ Huang, LH Peng - Molecular Therapy, 2021 - cell.com
Plant exosome-like nanovesicles, being innately replete with bioactive lipids, proteins, RNA,
and other pharmacologically active molecules, offer unique morphological and …

[PDF][PDF] Uptake, functionality, and re-release of extracellular vesicle-encapsulated cargo

K O'Brien, S Ughetto, S Mahjoum, AV Nair… - Cell reports, 2022 - cell.com
Extracellular vesicles (EVs) are membrane-encapsulated particles that carry genetically
active and protein/lipid cargo that can affect the function of the recipient cell. A number of …

Specificities of secretion and uptake of exosomes and other extracellular vesicles for cell-to-cell communication

M Mathieu, L Martin-Jaular, G Lavieu, C Théry - Nature cell biology, 2019 - nature.com
The ability of exosomes to transfer cargo from donor to acceptor cells, thereby triggering
phenotypic changes in the latter, has generated substantial interest in the scientific …

[HTML][HTML] The machinery of exosomes: biogenesis, release, and uptake

SV Krylova, D Feng - International Journal of Molecular Sciences, 2023 - mdpi.com
Exosomes are a subtype of membrane-contained vesicles 40–200 nm in diameter that are
secreted by cells into their surroundings. By transporting proteins, lipids, mRNA, miRNA …

Native and bioengineered extracellular vesicles for cardiovascular therapeutics

RC de Abreu, H Fernandes… - Nature reviews …, 2020 - nature.com
Extracellular vesicles (EVs) are a heterogeneous group of natural particles that are relevant
to the treatment of cardiovascular diseases. These endogenous vesicles have certain …

[HTML][HTML] Quantitative characterization of extracellular vesicle uptake and content delivery within mammalian cells

E Bonsergent, E Grisard, J Buchrieser… - Nature …, 2021 - nature.com
Extracellular vesicles (EVs), including exosomes, are thought to mediate intercellular
communication through the transfer of cargoes from donor to acceptor cells. Occurrence of …