Lyme disease in humans

JD Radolf, K Strle, JE Lemieux, F Strle - Current issues in molecular …, 2021 - mdpi.com
Lyme disease (Lyme borreliosis) is a tick-borne, zoonosis of adults and children caused by
genospecies of the Borrelia burgdorferi sensu lato complex. The ailment, widespread …

Lyme disease pathogenesis

J Coburn, B Garcia, LT Hu, MW Jewett… - Current issues in …, 2021 - mdpi.com
Lyme disease Borrelia are obligately parasitic, tick-transmitted, invasive, persistent bacterial
pathogens that cause disease in humans and non-reservoir vertebrates primarily through …

Of ticks, mice and men: understanding the dual-host lifestyle of Lyme disease spirochaetes

JD Radolf, MJ Caimano, B Stevenson… - Nature reviews …, 2012 - nature.com
In little more than 30 years, Lyme disease, which is caused by the spirochaete Borrelia
burgdorferi, has risen from relative obscurity to become a global public health problem and a …

Protein acetylation dynamics in response to carbon overflow in Escherichia coli

B Schilling, D Christensen, R Davis… - Molecular …, 2015 - Wiley Online Library
In E scherichia coli, acetylation of proteins at lysines depends largely on a non‐enzymatic
acetyl phosphate‐dependent mechanism. To assess the functional significance of this post …

The unique paradigm of spirochete motility and chemotaxis

NW Charon, A Cockburn, C Li, J Liu… - Annual review of …, 2012 - annualreviews.org
Spirochete motility is enigmatic: It differs from the motility of most other bacteria in that the
entire bacterium is involved in translocation in the absence of external appendages. Using …

Gene Regulation in Borrelia burgdorferi

DS Samuels - Annual review of microbiology, 2011 - annualreviews.org
Borrelia burgdorferi, the spirochete that causes Lyme disease, is maintained in nature via an
enzootic cycle that comprises a tick vector and a vertebrate host. Transmission from the tick …

Stage‐specific global alterations in the transcriptomes of L yme disease spirochetes during tick feeding and following mammalian host adaptation

R Iyer, MJ Caimano, A Luthra, D Axline Jr… - Molecular …, 2015 - Wiley Online Library
B orrelia burgdorferi, the agent of L yme disease, is maintained in nature within an enzootic
cycle involving a mammalian reservoir and an I xodes sp. tick vector. The transmission …

Gene regulation and transcriptomics

DS Samuels, MC Lybecker, XF Yang, Z Ouyang… - Current issues in …, 2021 - mdpi.com
Borrelia (Borreliella) burgdorferi, along with closely related species, is the etiologic agent of
Lyme disease. The spirochete subsists in an enzootic cycle that encompasses acquisition …

Interaction of the Lyme disease spirochete with its tick vector

MJ Caimano, D Drecktrah, F Kung… - Cellular …, 2016 - Wiley Online Library
Borrelia burgdorferi, the causative agent of Lyme disease (along with closely related
genospecies), is in the deeply branching spirochete phylum. The bacterium is maintained in …

Cyclic di-GMP is essential for the survival of the Lyme disease spirochete in ticks

M He, Z Ouyang, B Troxell, H Xu, A Moh… - PLoS …, 2011 - journals.plos.org
Cyclic dimeric GMP (c-di-GMP) is a bacterial second messenger that modulates many
biological processes. Although its role in bacterial pathogenesis during mammalian infection …