Frailty is an age-related clinical condition characterised by an increased susceptibility to
stressors and an elevated risk of adverse outcomes such as mortality. In the light of global …

Frailty is an age-related clinical state associated with deterioration across multiple
physiological systems and a leading cause of morbidity and mortality later in life. To …

Background Consistent and reproducible estimates of the underlying true level of frailty are
essential for risk stratification and monitoring of health changes. The purpose of this study is …

Background Frailty is a complex, dynamic geriatric condition, but limited evidence has
shown how genes and environment may contribute to its longitudinal changes. We sought to …

Age is a dominant risk factor for some of the most common neurological diseases. Biological
ageing encompasses interindividual variation in the rate of ageing and can be calculated …

Background Frailty is a common condition in older adults and has a major impact on patient
outcomes and service use. Information on the prevalence in middle-aged adults and the …

Background DNA methylation-derived epigenetic clocks and frailty are well-established
biological age measures capturing different aging processes. However, whether they are …

Background It is unclear whether frailty index (FI) change captures mortality risk better than
and independently of the current FI level, ie whether a regular FI assessment among older …

Background Frailty is a dynamic condition that is clinically expected to change in older
individuals during and around admission to an intermediate care (IC) facility. We aimed to …

We experience a life that is full of ups and downs. The ability to bounce back after adverse
life events such as the loss of a loved one or serious illness declines with age, and such …