Altered gene expression is a characteristic feature of many disease states such as
tumorigenesis, and in most cancers, it facilitates cancer cell survival and adaptation …

RNA-binding proteins (RBPs) are of fundamental importance for post-transcriptional gene
regulation and protein synthesis. They are required for pre-mRNA processing and for RNA …

Lysophospholipid signaling is emerging as a druggable regulator of pathophysiological
responses, and especially fibrosis, exemplified by the relative ongoing clinical trials in …

Autotaxin (ATX) is a secreted glycoprotein and functions as a key enzyme to produce
extracellular lysophosphatidic acid (LPA). LPA interacts with at least six G protein-coupled …

The RNA-binding protein human antigen R (HuR) is a well-established regulator of gene
expression at the posttranscriptional level. Its dysregulation has been implicated in various …

Autotaxin (ATX) is a member of the ectonucleotide pyrophosphate/phosphodiesterase
(ENPP) family; it is encoded by the ENPP2 gene. ATX is a secreted glycoprotein and …

Simple Summary Autotaxin (ATX) has been linked with the pathogenesis of several cancers
and especially with breast cancer (BC). BC is one of the most common cancers among …

RNA decay plays a major role in regulating gene expression and is tightly networked with
other aspects of gene expression to effectively coordinate post-transcriptional regulation …

Studies have found that RNA-binding proteins (RBPs) are dysfunctional and play a
significant regulatory role in the development of glioma. Based on The Cancer Genome …

A quarter-century after the discovery of autotaxin in cell culture, the autotaxin-
lysophosphatidate (LPA)-lipid phosphate phosphatase axis is now a promising clinical …