Current and future therapeutic approaches for osteosarcoma

DJ Harrison, DS Geller, JD Gill, VO Lewis… - Expert review of …, 2018 - Taylor & Francis
Introduction: Current treatment of osteosarcoma includes surgical resection of all gross
disease in conjunction with systemic chemotherapy to control micro-metastatic disease. This …

Osteosarcoma

BR Eaton, R Schwarz, R Vatner, B Yeh… - Pediatric blood & …, 2021 - Wiley Online Library
Osteosarcoma is a rare tumor that requires complex multidisciplinary management. This
paper reviews the general management and standard radiotherapy guidelines for …

Update on osteosarcoma

R Belayneh, MS Fourman, S Bhogal, KR Weiss - Current oncology reports, 2021 - Springer
Abstract Purpose of Review Osteosarcoma (OSA) is the most common primary tumor of
bone, mainly affecting children and adolescents. Here we discuss recent advances in …

Osteosarcoma: current treatment and a collaborative pathway to success

MS Isakoff, SS Bielack, P Meltzer… - Journal of clinical …, 2015 - ascopubs.org
Osteosarcoma is the bone tumor that most commonly affects children, adolescents, and
young adults. Before 1970, treatment primarily included surgical resection. However, the …

Targeting molecular mechanisms underlying treatment efficacy and resistance in osteosarcoma: a review of current and future strategies

I Lilienthal, N Herold - International journal of molecular sciences, 2020 - mdpi.com
Osteosarcoma is the most common primary malignant bone tumour in children and
adolescents. Due to micrometastatic spread, radical surgery alone rarely results in cure …

Germline and somatic genetics of osteosarcoma—connecting aetiology, biology and therapy

DM Gianferante, L Mirabello, SA Savage - Nature Reviews …, 2017 - nature.com
Clinical outcomes and treatment modalities for osteosarcoma, the most common primary
cancer of bone, have changed very little over the past 30 years. The peak incidence of …

Osteosarcoma treatment–where do we stand? A state of the art review

A Luetke, PA Meyers, I Lewis, H Juergens - Cancer treatment reviews, 2014 - Elsevier
Long-term outcome for patients with high-grade osteosarcoma has improved with the
addition of systemic chemotherapy, but subsequent progress has been less marked …

Progress in the chemotherapeutic treatment of osteosarcoma

Y Zhang, J Yang, N Zhao, C Wang… - Oncology …, 2018 - spandidos-publications.com
Osteosarcoma (OS) is the most common type of primary bone tumor in children and
adolescents and has been associated with a high degree of malignancy, early metastasis …

Osteosarcoma

DD Moore, HH Luu - Orthopaedic oncology: primary and metastatic tumors …, 2014 - Springer
Osteosarcoma is a malignant tumor that primarily affects the long bones but can also involve
other bones in the body. It has a bimodal distribution with peaks in the second decade of life …

Prognostic factors in high-grade osteosarcoma of the extremities or trunk: an analysis of 1,702 patients treated on neoadjuvant cooperative osteosarcoma study group …

SS Bielack, B Kempf-Bielack, G Delling… - Journal of clinical …, 2002 - ascopubs.org
PURPOSE: To define prognostic factors for response and long-term outcome for a wide
spectrum of osteosarcomas, extending well beyond those of the typical young patient with …