Degradation of mitochondria via a selective form of autophagy, named mitophagy, is a
fundamental mechanism conserved from yeast to humans that regulates mitochondrial …

The maintenance of a healthy and functional mitochondrial network is critical during
development as well as throughout life in the response to physiological adaptations and …

Understanding tissue macrophage biology has become challenging in recent years due the
ever-increasing complexity in macrophage-subset identification and functional …

Age is the most important risk factor for most diseases. Mitochondria play a central role in
bioenergetics and metabolism. In addition, several lines of evidence indicate the impact of …

The aging population is increasing in developed countries. Because the incidence of
cardiac disease increases dramatically with age, it is important to understand the molecular …

Biological aging is an inevitable and independent risk factor for a wide array of chronic
diseases including cardiovascular and metabolic diseases. Ample evidence has established …

A large body of evidence indicates that mitochondrial dysfunction has a major role in the
pathogenesis of multiple cardiovascular disorders. Over the past 2 decades, extraordinary …

The elimination of mitochondria via autophagy, termed mitophagy, is an evolutionarily
conserved mechanism for mitochondrial quality control and homeostasis. Mitophagy …

Mitochondrial function is key to support metabolism and homeostasis in the retina, an organ
that has one of the highest metabolic rates body-wide and is constantly exposed to …

Atherosclerosis is a multifactorial inflammatory pathology that involves metabolic processes.
Improvements in therapy have drastically reduced the prognosis of cardiovascular disease …