Climate change with altered pest-disease dynamics and rising abiotic stresses threatens
resource-constrained agricultural production systems worldwide. Genomics-assisted …

Abstract Here the Human Pangenome Reference Consortium presents a first draft of the
human pangenome reference. The pangenome contains 47 phased, diploid assemblies …

The current human reference genome, GRCh38, represents over 20 years of effort to
generate a high-quality assembly, which has benefitted society,. However, it still has many …

High-quality genome chromosome-scale sequences provide an important basis for
genomics downstream analysis, especially the construction of haplotype-resolved and …

Haplotype-level allelic characterization facilitates research on the functional, evolutionary
and breeding-related features of extremely large and complex plant genomes. We report a …

Bioethanol is a sustainable energy alternative and can contribute to global greenhouse-gas
emission reductions by over 60%. Its industrial production faces various bottlenecks …

Motivation Long-read phasing has been used for reconstructing diploid genomes, improving
variant calling and resolving microbial strains in metagenomics. However, the phasing …

Single-cell whole-genome haplotyping allows simultaneous detection of haplotypes
associated with monogenic diseases, chromosome copy-numbering and subsequently, has …

Cancer genomes are highly complex and heterogeneous. The standard short-read
sequencing and analytical methods are unable to provide the complete and precise base …

Haplotype information is crucial for biomedical and population genetics research. However,
current strategies to produce de novo haplotype-resolved assemblies often require either …