[HTML][HTML] Current applications and different approaches for microbial L-asparaginase production

JJM Cachumba, FAF Antunes, GFD Peres… - Brazilian journal of …, 2016 - SciELO Brasil
ABSTRACT L-asparaginase (EC 3.5. 1.1) is an enzyme that catalysis mainly the asparagine
hydrolysis in L-aspartic acid and ammonium. This enzyme is presented in different …

Development of L-asparaginase biobetters: current research status and review of the desirable quality profiles

LP Brumano, FVS da Silva, TA Costa-Silva… - … in bioengineering and …, 2019 - frontiersin.org
L-Asparaginase (ASNase) is a vital component of the first line treatment of acute
lymphoblastic leukemia (ALL), an aggressive type of blood cancer expected to afflict over …

L-asparaginase production review: bioprocess design and biochemical characteristics

D Castro, ASC Marques, MR Almeida… - Applied microbiology …, 2021 - Springer
In the past decades, the production of biopharmaceuticals has gained high interest due to its
great sensitivity, specificity, and lower risk of negative effects to patients. Biopharmaceuticals …

Microbes producing L-asparaginase free of glutaminase and urease isolated from extreme locations of Antarctic soil and moss

A Ashok, K Doriya, JV Rao, A Qureshi, AK Tiwari… - Scientific reports, 2019 - nature.com
L-Asparaginase (L-asparagine aminohydrolase, EC 3.5. 1.1) has been proven to be
competent in treating Acute Lymphoblastic Leukaemia (ALL), which is widely observed in …

Microbial L-asparaginase as a promising enzyme for treatment of various cancers

F Darvishi, Z Jahanafrooz, A Mokhtarzadeh - Applied Microbiology and …, 2022 - Springer
Metabolic differences between normal and cancerous cells have been used as a point of
view for developing anticancer drugs. Some degrading enzymes of certain amino acids …

Enhanced extracellular production of L-asparaginase from Bacillus subtilis 168 by B. subtilis WB600 through a combined strategy

Y Feng, S Liu, Y Jiao, H Gao, M Wang, G Du… - Applied microbiology and …, 2017 - Springer
Abstract L-asparaginase (EC 3.5. 1.1, ASN) exhibits great commercial value due to its uses
in the food and medicine industry. In this study, we reported the enhanced expression of …

A Novel L-Asparaginase from Hyperthermophilic Archaeon Thermococcus sibiricus: Heterologous Expression and Characterization for Biotechnology Application

M Dumina, A Zhgun, M Pokrovskaya… - International Journal of …, 2021 - mdpi.com
L-asparaginase (L-ASNase) is a vital enzyme with a broad range of applications in medicine
and food industry. Drawbacks of current commercial L-ASNases stimulate the search for …

Development and catalytic characterization of L-asparaginase nano-bioconjugates

S Agrawal, N Kango - International journal of biological macromolecules, 2019 - Elsevier
The present paper describes efficient immobilization of L-glutaminase free L-asparaginase
for developing a new therapeutic system for anticancer therapy. L-asparaginase (L-ASNase) …

Highly efficient novel recombinant L-asparaginase with no glutaminase activity from a new halo-thermotolerant Bacillus strain

A Safary, R Moniri, M Hamzeh-Mivehroud… - BioImpacts …, 2018 - pmc.ncbi.nlm.nih.gov
Introduction: The bacterial enzyme has gained more attention in therapeutic application
because of the higher substrate specificity and longer half-life. L-asparaginase is an …

Heterologous expression and molecular modelling of L-asparaginase from Bacillus subtilis ETMC-2

S Agrawal, UK Jana, N Kango - International Journal of Biological …, 2021 - Elsevier
Bacterial L-asparaginase is the key therapeutic enzyme in cancer therapy and is also
witnessing demand as a food processing aid. In this study, L-asparaginase of newly isolated …