[HTML][HTML] Current applications and different approaches for microbial L-asparaginase production
JJM Cachumba, FAF Antunes, GFD Peres… - Brazilian journal of …, 2016 - SciELO Brasil
ABSTRACT L-asparaginase (EC 3.5. 1.1) is an enzyme that catalysis mainly the asparagine
hydrolysis in L-aspartic acid and ammonium. This enzyme is presented in different …
hydrolysis in L-aspartic acid and ammonium. This enzyme is presented in different …
Development of L-asparaginase biobetters: current research status and review of the desirable quality profiles
LP Brumano, FVS da Silva, TA Costa-Silva… - … in bioengineering and …, 2019 - frontiersin.org
L-Asparaginase (ASNase) is a vital component of the first line treatment of acute
lymphoblastic leukemia (ALL), an aggressive type of blood cancer expected to afflict over …
lymphoblastic leukemia (ALL), an aggressive type of blood cancer expected to afflict over …
L-asparaginase production review: bioprocess design and biochemical characteristics
D Castro, ASC Marques, MR Almeida… - Applied microbiology …, 2021 - Springer
In the past decades, the production of biopharmaceuticals has gained high interest due to its
great sensitivity, specificity, and lower risk of negative effects to patients. Biopharmaceuticals …
great sensitivity, specificity, and lower risk of negative effects to patients. Biopharmaceuticals …
Microbes producing L-asparaginase free of glutaminase and urease isolated from extreme locations of Antarctic soil and moss
L-Asparaginase (L-asparagine aminohydrolase, EC 3.5. 1.1) has been proven to be
competent in treating Acute Lymphoblastic Leukaemia (ALL), which is widely observed in …
competent in treating Acute Lymphoblastic Leukaemia (ALL), which is widely observed in …
Microbial L-asparaginase as a promising enzyme for treatment of various cancers
Metabolic differences between normal and cancerous cells have been used as a point of
view for developing anticancer drugs. Some degrading enzymes of certain amino acids …
view for developing anticancer drugs. Some degrading enzymes of certain amino acids …
Enhanced extracellular production of L-asparaginase from Bacillus subtilis 168 by B. subtilis WB600 through a combined strategy
Y Feng, S Liu, Y Jiao, H Gao, M Wang, G Du… - Applied microbiology and …, 2017 - Springer
Abstract L-asparaginase (EC 3.5. 1.1, ASN) exhibits great commercial value due to its uses
in the food and medicine industry. In this study, we reported the enhanced expression of …
in the food and medicine industry. In this study, we reported the enhanced expression of …
A Novel L-Asparaginase from Hyperthermophilic Archaeon Thermococcus sibiricus: Heterologous Expression and Characterization for Biotechnology Application
M Dumina, A Zhgun, M Pokrovskaya… - International Journal of …, 2021 - mdpi.com
L-asparaginase (L-ASNase) is a vital enzyme with a broad range of applications in medicine
and food industry. Drawbacks of current commercial L-ASNases stimulate the search for …
and food industry. Drawbacks of current commercial L-ASNases stimulate the search for …
Development and catalytic characterization of L-asparaginase nano-bioconjugates
The present paper describes efficient immobilization of L-glutaminase free L-asparaginase
for developing a new therapeutic system for anticancer therapy. L-asparaginase (L-ASNase) …
for developing a new therapeutic system for anticancer therapy. L-asparaginase (L-ASNase) …
Highly efficient novel recombinant L-asparaginase with no glutaminase activity from a new halo-thermotolerant Bacillus strain
A Safary, R Moniri, M Hamzeh-Mivehroud… - BioImpacts …, 2018 - pmc.ncbi.nlm.nih.gov
Introduction: The bacterial enzyme has gained more attention in therapeutic application
because of the higher substrate specificity and longer half-life. L-asparaginase is an …
because of the higher substrate specificity and longer half-life. L-asparaginase is an …
Heterologous expression and molecular modelling of L-asparaginase from Bacillus subtilis ETMC-2
Bacterial L-asparaginase is the key therapeutic enzyme in cancer therapy and is also
witnessing demand as a food processing aid. In this study, L-asparaginase of newly isolated …
witnessing demand as a food processing aid. In this study, L-asparaginase of newly isolated …