The host inflammatory response against infections is characterized by the release of pro-
inflammatory cytokines and acute-phase proteins, driving both innate and adaptive arms of …

Sepsis and septic shock are among the leading causes of death in intensive care units
worldwide. Numerous studies on their pathophysiology have revealed an imbalance in the …

Sepsis is an unusual systemic reaction to what is sometimes an otherwise ordinary infection,
and it probably represents a pattern of response by the immune system to injury. A hyper …

Pyroptosis is a programmed necrotic cell death executed by gasdermins, a family of pore-
forming proteins. The cleavage of gasdermins by specific proteases enables their pore …

The polypeptide cytokine interleukin-1 (IL-1) affects nearly every tissue and organ system. IL-
1 is the prototype of the pro-inflammatory cytokines in that it induces the expression of a …

Objective.—To further define the safety and efficacy of recombinant human interleukin 1
receptor antagonist (rhIL-1ra) in the treatment of sepsis syndrome. Study Design …

Multiple organ failure (MOF) has reached epidemic proportions in most intensive care units
and is fast becoming the most common cause of death in the surgical intensive care unit …

Background A recombinant, soluble fusion protein that is a dimer of an extracellular portion
of the human tumor necrosis factor (TNF) receptor and the Fc portion of IgG1 (TNFR: Fc) …

Forty critically ill surgical patients with documented infections were studied during their stay
in an intensive care unit. Among these patients, 19 developed septic shock and 16 died, 9 of …

The production by monocytes of interleukin-1 alpha (IL-1 alpha), interleukin-1 beta (IL-1
beta), interleukin-6 (IL-6), and tumor necrosis factor alpha (TNF alpha) in intensive care unit …