Skyline is a freely available, open‐source Windows client application for accelerating
targeted proteomics experimentation, with an emphasis on the proteomics and mass …

The life sciences are currently being transformed by an unprecedented wave of
developments in molecular analysis, which include important advances in instrumental …

for processing and analyzing complex proteomics data sets in a platform-agnostic manner
has become critical. With version 3.0 of the ProteoWizard Toolkit8, we attempt to mitigate …

Proteomics research routinely involves identifying peptides and proteins via MS/MS
sequence database search. Thus the database search engine is an integral tool in many …

The complex, rapidly evolving field of computational metabolomics calls for collaborative
infrastructures where the large volume of new algorithms for data pre-processing, statistical …

Background Spectral library searching is currently the most common approach for
compound annotation in untargeted metabolomics. Spectral libraries applicable to liquid …

Cysteine is the most intrinsically nucleophilic amino acid in proteins, where its reactivity is
tuned to perform diverse biochemical functions. The absence of a consensus sequence that …

Cancer cells exhibit several unique metabolic phenotypes that are critical for cell growth and
proliferation. Specifically, they overexpress the M2 isoform of the tightly regulated enzyme …

Secretion of extracellular vesicles is a general cellular activity that spans the range from
simple unicellular organisms (eg archaea; Gram‐positive and Gram‐negative bacteria) to …

Introduction Metabolomics is increasingly being used in the clinical setting for disease
diagnosis, prognosis and risk prediction. Machine learning algorithms are particularly …