In the mid-1980s, the identification of serine and threonine residues on nuclear and
cytoplasmic proteins modified by a N-acetylglucosamine moiety (O-GlcNAc) via an O …

Aerobic exercise training and resistance exercise training are both well-known for their
ability to improve human health; especially in individuals with type 2 diabetes. However …

The skeletal muscle is the largest organ in the body, by mass. It is also the regulator of
glucose homeostasis, responsible for 80% of postprandial glucose uptake from the …

Alterations in glucose and glutamine utilizing pathways and in fatty acid metabolism are
currently considered the most significant and prevalent metabolic changes observed in …

Mitochondrial movement and distribution are fundamental to their function. Here we report a
mechanism that regulates mitochondrial movement by anchoring mitochondria to the F-actin …

O-GlcNAc transferase (OGT), found in the nucleus and cytoplasm of all mammalian cell
types, is essential for cell proliferation. Why OGT is required for cell growth is not known …

The mammalian Sirtuins (SIRT1-7) are an evolutionarily conserved family of NAD+-
dependent deacylase and mono-ADP-ribosyltransferase. Sirtuins display distinct subcellular …

A high-fat diet often leads to excessive fat deposition and adversely affects the organism.
However, the mechanism of liver fat deposition induced by high fat is still unclear. Therefore …

The ventromedial hypothalamus (VMH) is known to regulate body weight and
counterregulatory response. However, how VMH neurons regulate lipid metabolism and …

O-GlcNAcylation corresponds to the addition of N-Acetylglucosamine (GlcNAc) on serine or
threonine residues of cytosolic, nuclear and mitochondrial proteins. This reversible …