Bortezomib, a first-generation proteasome inhibitor widely used in chemotherapy for
hematologic malignancy, has effective anti-cancer activity but often causes severe …

Chemotherapy-induced peripheral neuropathy (CIPN) is a somatosensory axonopathy in
cancer patients receiving any of a variety of widely-use antitumor agents. CIPN can lead to …

Traumatic brain injury (TBI) is the largest non-genetic, non-aging related risk factor for
Alzheimer's disease (AD). We report here that TBI induces tau acetylation (ac-tau) at sites …

The decline of nicotinamide adenine dinucleotide (NAD) occurs in a variety of human
pathologies including neurodegeneration. NAD-boosting agents can provide …

Many chronic pain conditions show sex differences in their epidemiology. This could be
attributed to sex-dependent differential expression of genes (DEGs) involved in nociceptive …

Several first-line chemotherapeutic agents, including taxanes, platinum agents and
proteasome inhibitors, are associated with the dose-limiting side effect of chemotherapy …

Nicotinamide adenine dinucleotide (NAD) is an essential coenzyme that mediates various
redox reactions. Particularly, mitochondrial NAD plays a critical role in energy production …

Chronic pain is the leading cause of disability worldwide and is commonly associated with
comorbid disorders. However, the role of diet in chronic pain is poorly understood. Of …

Chemotherapy-induced peripheral neuropathy (CIPN) is a severe adverse effect observed
in most patients treated with neurotoxic anti-cancer drugs. Currently, there are no …

Traumatic brain injury (TBI) is a leading worldwide cause of disability, and there are
currently no medicines that prevent, reduce, or reverse acute or chronic neurodegeneration …