Premature infants are exposed to increased generation of reactive oxygen species, and on
the other hand, they have a deficient antioxidant defense system. Oxidative insult is a salient …

The transition from a fetus to a newborn is the most complex physiologic adaptation that
occurs in human experience. Before medicalization of delivery, the transition had to occur …

To date, studies suggest that biological signaling by nitric oxide (NO) is primarily mediated
by cGMP, which is synthesized by NO-activated guanylyl cyclases and broken down by …

The superfamily of cyclic nucleotide (cN) phosphodiesterases (PDEs) is comprised of 11
families of enzymes. PDEs break down cAMP and/or cGMP and are major determinants of …

Thirty years ago, there was an emerging appreciation for the significance of oxidative stress
in newborn disease. This prompted a renewed interest in the impact of oxygen therapy for …

Pathophysiology and Management of Persistent Pulmonary Hypertension of the Newborn -
Clinics in Perinatology Skip to Main Content Advertisement Clinics in Perinatology Log in …

Pulmonary vascular disease can be defined as either a disease affecting the pulmonary
capillaries and pulmonary arterioles, termed pulmonary arterial hypertension, or a disease …

When the normal cardiopulmonary transition fails to occur, the result is persistent pulmonary
hypertension of the newborn. Severe persistent pulmonary hypertension of the newborn is …

OBJECTIVE: To evaluate the safety of intravenous (IV) sildenafil, an inhibitor of cyclic
guanosine monophosphate–specific phosphodiesterase, in treating near-term and term …

Pulmonary hypertension (PH) is a common complication of neonatal respiratory diseases,
including bronchopulmonary dysplasia (BPD), and recent studies have increased …