The incidence and prevalence of heart failure with preserved ejection fraction (HFpEF)
continue to rise in tandem with the increasing age and burdens of obesity, sedentariness …

Approximately half of all patients with heart failure (HF) have a preserved ejection fraction,
and the prevalence is growing rapidly given the aging population in many countries and the …

Background Chronotropic incompetence has shown to be associated with a decrease in
exercise capacity in heart failure with preserved ejection fraction (HFpEF), yet β-blockers are …

Although patients with heart failure with preserved ejection fraction (HFpEF)(left ventricular
ejection fraction≥ 50%) comprise nearly half of those with chronic heart failure, evidence …

Importance Reduced heart rate during exercise is common and associated with impaired
aerobic capacity in heart failure with preserved ejection fraction (HFpEF), but it remains …

For decades, heart failure with preserved ejection fraction (HFpEF) proved an elusive entity
to treat. Sodium-glucose cotransporter 2 (SGLT2) inhibitors have recently been shown to …

Heart failure with preserved ejection fraction (HFpEF) accounts for nearly half of all heart
failure cases and has a prevalence that is expected to rise with the growing ageing …

Background: Exercise intolerance is a defining characteristic of heart failure with preserved
ejection fraction (HFpEF). A marked rise in pulmonary capillary wedge pressure (PCWP) …

Background: The ability to increase heart rate during exercise and other stressors is a key
homeostatic feature of the sinoatrial node (SAN). When the physiological heart rate …

Heart failure threatens the lives of patients and reduces their quality of life. Heart failure,
especially heart failure with preserved ejection fraction, is closely related to systemic and …