[PDF][PDF] Hallmarks of neurodegenerative diseases
DM Wilson, MR Cookson, L Van Den Bosch… - Cell, 2023 - cell.com
Decades of research have identified genetic factors and biochemical pathways involved in
neurodegenerative diseases (NDDs). We present evidence for the following eight hallmarks …
neurodegenerative diseases (NDDs). We present evidence for the following eight hallmarks …
[HTML][HTML] The microbiota-gut-brain axis
I. INTRODUCTION 1877 II. STUDYING THE... 1881 III. MICROBIOTA-GUT-BRAIN AXIS...
1907 IV. PATHWAYS OF COMMUNICATION 1911 V. MICROBIOTA AND SYNAPTIC... 1929 …
1907 IV. PATHWAYS OF COMMUNICATION 1911 V. MICROBIOTA AND SYNAPTIC... 1929 …
[HTML][HTML] Perivascular cells induce microglial phagocytic states and synaptic engulfment via SPP1 in mouse models of Alzheimer's disease
Alzheimer's disease (AD) is characterized by synaptic loss, which can result from
dysfunctional microglial phagocytosis and complement activation. However, what signals …
dysfunctional microglial phagocytosis and complement activation. However, what signals …
The neuronal pentraxin Nptx2 regulates complement activity and restrains microglia-mediated synapse loss in neurodegeneration
Complement overactivation mediates microglial synapse elimination in neurological
diseases such as Alzheimer's disease (AD) and frontotemporal dementia (FTD), but how …
diseases such as Alzheimer's disease (AD) and frontotemporal dementia (FTD), but how …
[HTML][HTML] Quercetin hinders microglial activation to alleviate neurotoxicity via the interplay between NLRP3 inflammasome and mitophagy
X Han, T Xu, Q Fang, H Zhang, L Yue, G Hu, L Sun - Redox Biology, 2021 - Elsevier
Activated microglia are an important type of innate immune cell in the brain, and they secrete
inflammatory cytokines into the extracellular milieu, exert neurotoxicity to surrounding …
inflammatory cytokines into the extracellular milieu, exert neurotoxicity to surrounding …
Microglia in neurodegeneration
The neuroimmune system is involved in development, normal functioning, aging, and injury
of the central nervous system. Microglia, first described a century ago, are the main …
of the central nervous system. Microglia, first described a century ago, are the main …
[HTML][HTML] Microglial regional heterogeneity and its role in the brain
YL Tan, Y Yuan, L Tian - Molecular psychiatry, 2020 - nature.com
Microglia have been recently shown to manifest a very interesting phenotypical
heterogeneity across different regions in the mammalian central nervous system (CNS) …
heterogeneity across different regions in the mammalian central nervous system (CNS) …
[HTML][HTML] Microglia in neurological diseases: a road map to brain-disease dependent-inflammatory response
S Bachiller, I Jiménez-Ferrer, A Paulus… - Frontiers in cellular …, 2018 - frontiersin.org
Microglia represent a specialized population of macrophages-like cells in the central
nervous system (CNS) considered immune sentinels that are capable of orchestrating a …
nervous system (CNS) considered immune sentinels that are capable of orchestrating a …
[PDF][PDF] GABA-receptive microglia selectively sculpt developing inhibitory circuits
Microglia, the resident immune cells of the brain, have emerged as crucial regulators of
synaptic refinement and brain wiring. However, whether the remodeling of distinct synapse …
synaptic refinement and brain wiring. However, whether the remodeling of distinct synapse …
[HTML][HTML] Progranulin as a therapeutic target in neurodegenerative diseases
Progranulin (PGRN, encoded by the GRN gene) plays a key role in the development,
survival, function, and maintenance of neurons and microglia in the mammalian brain. It …
survival, function, and maintenance of neurons and microglia in the mammalian brain. It …