BCG-induced cross-protection and development of trained immunity: implication for vaccine design
C Covián, A Fernández-Fierro, A Retamal-Díaz… - Frontiers in …, 2019 - frontiersin.org
The Bacillus Calmette-Guérin (BCG) is a live attenuated tuberculosis vaccine that has the
ability to induce non-specific cross-protection against pathogens that might be unrelated to …
ability to induce non-specific cross-protection against pathogens that might be unrelated to …
What have we learnt about BCG vaccination in the last 20 years?
HM Dockrell, SG Smith - Frontiers in immunology, 2017 - frontiersin.org
A number of new tuberculosis (TB) vaccines have been or are entering clinical trials, which
include genetically modified mycobacteria, mycobacterial antigens delivered by viral …
include genetically modified mycobacteria, mycobacterial antigens delivered by viral …
Immune Responses to Bacillus Calmette–Guérin Vaccination: Why Do They Fail to Protect against Mycobacterium tuberculosis?
Mycobacterium tuberculosis (M. tb), the causative agent of tuberculosis (TB), is the current
leading cause of death due to a single infectious organism. Although curable, the broad …
leading cause of death due to a single infectious organism. Although curable, the broad …
The humoral immune response to BCG vaccination
R Tanner, B Villarreal-Ramos… - Frontiers in …, 2019 - frontiersin.org
Bacillus Calmette Guérin (BCG) is the only currently available vaccine against tuberculosis
(TB), but it confers incomplete and variable protection against pulmonary TB in humans and …
(TB), but it confers incomplete and variable protection against pulmonary TB in humans and …
Tuberculosis vaccines and prevention of infection
TR Hawn, TA Day, TJ Scriba, M Hatherill… - Microbiology and …, 2014 - Am Soc Microbiol
Tuberculosis (TB) is a leading cause of death worldwide despite the availability of effective
chemotherapy for over 60 years. Although Mycobacterium bovis bacillus Calmette-Guérin …
chemotherapy for over 60 years. Although Mycobacterium bovis bacillus Calmette-Guérin …
B-cells and antibodies as contributors to effector immune responses in tuberculosis
WF Rijnink, THM Ottenhoff, SA Joosten - Frontiers in immunology, 2021 - frontiersin.org
Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), is still a major threat to
mankind, urgently requiring improved vaccination and therapeutic strategies to reduce TB …
mankind, urgently requiring improved vaccination and therapeutic strategies to reduce TB …
Central Memory CD4+ T Cells Are Responsible for the Recombinant Bacillus Calmette-Guérin ΔureC::hly Vaccine's Superior Protection Against Tuberculosis
A Vogelzang, C Perdomo, U Zedler… - The Journal of …, 2014 - academic.oup.com
Abstract Bacillus Calmette-Guérin (BCG) has been used for vaccination against tuberculosis
for nearly a century. Here, we analyze immunity induced by a live tuberculosis vaccine …
for nearly a century. Here, we analyze immunity induced by a live tuberculosis vaccine …
The double-sided effects of Mycobacterium Bovis bacillus Calmette–Guérin vaccine
J Li, L Zhan, C Qin - npj Vaccines, 2021 - nature.com
Abstract Bacillus Calmette–Guérin (BCG), the only vaccine proven to be effective against
tuberculosis (TB), is the most commonly used vaccine globally. In addition to its effects on …
tuberculosis (TB), is the most commonly used vaccine globally. In addition to its effects on …
Precision vaccine development: cues from natural immunity
Traditional vaccine development against infectious diseases has been guided by the
overarching aim to generate efficacious vaccines normally indicated by an antibody and/or …
overarching aim to generate efficacious vaccines normally indicated by an antibody and/or …
Recombinant BCG: innovations on an old vaccine. Scope of BCG strains and strategies to improve long-lasting memory
AC da Costa, SV Nogueira, A Kipnis… - Frontiers in …, 2014 - frontiersin.org
Bacille Calmette–Guérin (BCG), an attenuated vaccine derived from Mycobacterium bovis, is
the current vaccine of choice against tuberculosis (TB). Despite its protection against active …
the current vaccine of choice against tuberculosis (TB). Despite its protection against active …