BCG-induced cross-protection and development of trained immunity: implication for vaccine design

C Covián, A Fernández-Fierro, A Retamal-Díaz… - Frontiers in …, 2019 - frontiersin.org
The Bacillus Calmette-Guérin (BCG) is a live attenuated tuberculosis vaccine that has the
ability to induce non-specific cross-protection against pathogens that might be unrelated to …

What have we learnt about BCG vaccination in the last 20 years?

HM Dockrell, SG Smith - Frontiers in immunology, 2017 - frontiersin.org
A number of new tuberculosis (TB) vaccines have been or are entering clinical trials, which
include genetically modified mycobacteria, mycobacterial antigens delivered by viral …

Immune Responses to Bacillus Calmette–Guérin Vaccination: Why Do They Fail to Protect against Mycobacterium tuberculosis?

JI Moliva, J Turner, JB Torrelles - Frontiers in immunology, 2017 - frontiersin.org
Mycobacterium tuberculosis (M. tb), the causative agent of tuberculosis (TB), is the current
leading cause of death due to a single infectious organism. Although curable, the broad …

The humoral immune response to BCG vaccination

R Tanner, B Villarreal-Ramos… - Frontiers in …, 2019 - frontiersin.org
Bacillus Calmette Guérin (BCG) is the only currently available vaccine against tuberculosis
(TB), but it confers incomplete and variable protection against pulmonary TB in humans and …

Tuberculosis vaccines and prevention of infection

TR Hawn, TA Day, TJ Scriba, M Hatherill… - Microbiology and …, 2014 - Am Soc Microbiol
Tuberculosis (TB) is a leading cause of death worldwide despite the availability of effective
chemotherapy for over 60 years. Although Mycobacterium bovis bacillus Calmette-Guérin …

B-cells and antibodies as contributors to effector immune responses in tuberculosis

WF Rijnink, THM Ottenhoff, SA Joosten - Frontiers in immunology, 2021 - frontiersin.org
Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), is still a major threat to
mankind, urgently requiring improved vaccination and therapeutic strategies to reduce TB …

Central Memory CD4+ T Cells Are Responsible for the Recombinant Bacillus Calmette-Guérin ΔureC::hly Vaccine's Superior Protection Against Tuberculosis

A Vogelzang, C Perdomo, U Zedler… - The Journal of …, 2014 - academic.oup.com
Abstract Bacillus Calmette-Guérin (BCG) has been used for vaccination against tuberculosis
for nearly a century. Here, we analyze immunity induced by a live tuberculosis vaccine …

The double-sided effects of Mycobacterium Bovis bacillus Calmette–Guérin vaccine

J Li, L Zhan, C Qin - npj Vaccines, 2021 - nature.com
Abstract Bacillus Calmette–Guérin (BCG), the only vaccine proven to be effective against
tuberculosis (TB), is the most commonly used vaccine globally. In addition to its effects on …

Precision vaccine development: cues from natural immunity

S Barman, D Soni, B Brook, E Nanishi… - Frontiers in …, 2022 - frontiersin.org
Traditional vaccine development against infectious diseases has been guided by the
overarching aim to generate efficacious vaccines normally indicated by an antibody and/or …

Recombinant BCG: innovations on an old vaccine. Scope of BCG strains and strategies to improve long-lasting memory

AC da Costa, SV Nogueira, A Kipnis… - Frontiers in …, 2014 - frontiersin.org
Bacille Calmette–Guérin (BCG), an attenuated vaccine derived from Mycobacterium bovis, is
the current vaccine of choice against tuberculosis (TB). Despite its protection against active …