Uveoscleral outflow–a review
A Alm, SFE Nilsson - Experimental eye research, 2009 - Elsevier
The uveoscleral outflow route was described more than 40years ago. Part of aqueous
leaves the eye through the iris root. The ciliary muscle, and there are large species …
leaves the eye through the iris root. The ciliary muscle, and there are large species …
Matrix metalloproteinases and glaucoma treatment
RN Weinreb, MR Robinson, M Dibas… - Journal of Ocular …, 2020 - liebertpub.com
Matrix metalloproteinases (MMPs) are a family of proteolytic enzymes that degrade
extracellular matrix (ECM) components such as collagen and have important roles in …
extracellular matrix (ECM) components such as collagen and have important roles in …
Prostaglandins increase matrix metalloproteinase release from human ciliary smooth muscle cells.
RN Weinreb, K Kashiwagi, F Kashiwagi… - … & visual science, 1997 - iovs.arvojournals.org
PURPOSE: To identify matrix metalloproteinases (MMPs) released by ciliary smooth muscle
cells in vitro and to determine whether MMP release is altered by exposure to …
cells in vitro and to determine whether MMP release is altered by exposure to …
Effects of prostaglandins on the aqueous humor outflow pathways
RN Weinreb, CB Toris, TG B'Ann, JD Lindsey… - Survey of …, 2002 - Elsevier
Topical treatments with certain prostaglandins (PGs), including FP receptor agonists, lower
intraocular pressure by increasing uveoscleral outflow. Although the precise mechanism for …
intraocular pressure by increasing uveoscleral outflow. Although the precise mechanism for …
Effects of prostaglandin analogues on aqueous humor outflow pathways
NS Winkler, MP Fautsch - Journal of Ocular Pharmacology and …, 2014 - liebertpub.com
Elevated intraocular pressure (IOP) is the most prevalent risk factor for glaucoma. All
treatments, whether surgical or pharmaceutical, are aimed at lowering IOP. Prostaglandin …
treatments, whether surgical or pharmaceutical, are aimed at lowering IOP. Prostaglandin …
Myocilin and glaucoma: facts and ideas
ER Tamm - Progress in retinal and eye research, 2002 - Elsevier
Mutations in the MYOC gene that encodes for myocilin are causative for some forms of
juvenile and adult-onset primary open-angle glaucoma (POAG). Myocilin is a secreted 55 …
juvenile and adult-onset primary open-angle glaucoma (POAG). Myocilin is a secreted 55 …
From PGF2α-Isopropyl Ester to Latanoprost: A Review of the Development of Xalatan The Proctor Lecture
JW Stjernschantz - Investigative Ophthalmology & Visual …, 2001 - iovs.arvojournals.org
The research that led to the concept of using prostaglandins for reduction of intraocular
pressure (IOP) has been discussed by Bito and goes back to the early 1980s, when it was …
pressure (IOP) has been discussed by Bito and goes back to the early 1980s, when it was …
Effect of latanoprost on the extracellular matrix of the ciliary muscle. A study on cultured cells and tissue sections
A OCKLIND - Experimental eye research, 1998 - Elsevier
Prostaglandin F2αand its analogue latanoprost, both prostanoid FP receptor agonists,
reduce the intraocular pressure mainly by enhancing uveoscleral outflow. Changes in the …
reduce the intraocular pressure mainly by enhancing uveoscleral outflow. Changes in the …
Topical prostaglandin F2α treatment reduces collagen types I, III, and IV in the monkey uveoscleral outflow pathway
T Sagara, DD Gaton, JD Lindsey… - Archives of …, 1999 - jamanetwork.com
Background Topical prostaglandin F 2α isopropyl ester increases uveoscleral outflow in
monkeys and humans. Objective To investigate the effects of prostaglandin F 2α isopropyl …
monkeys and humans. Objective To investigate the effects of prostaglandin F 2α isopropyl …
Prostaglandins in the eye: Function, expression, and roles in glaucoma
LP Doucette, MA Walter - Ophthalmic genetics, 2017 - Taylor & Francis
Prostaglandins are small pro-inflammatory molecules derived from arachidonic acid that
play roles in a multitude of biological processes including, but not limited to, inflammation …
play roles in a multitude of biological processes including, but not limited to, inflammation …