The uveoscleral outflow route was described more than 40years ago. Part of aqueous
leaves the eye through the iris root. The ciliary muscle, and there are large species …

Matrix metalloproteinases (MMPs) are a family of proteolytic enzymes that degrade
extracellular matrix (ECM) components such as collagen and have important roles in …

PURPOSE: To identify matrix metalloproteinases (MMPs) released by ciliary smooth muscle
cells in vitro and to determine whether MMP release is altered by exposure to …

Topical treatments with certain prostaglandins (PGs), including FP receptor agonists, lower
intraocular pressure by increasing uveoscleral outflow. Although the precise mechanism for …

Elevated intraocular pressure (IOP) is the most prevalent risk factor for glaucoma. All
treatments, whether surgical or pharmaceutical, are aimed at lowering IOP. Prostaglandin …

Mutations in the MYOC gene that encodes for myocilin are causative for some forms of
juvenile and adult-onset primary open-angle glaucoma (POAG). Myocilin is a secreted 55 …

The research that led to the concept of using prostaglandins for reduction of intraocular
pressure (IOP) has been discussed by Bito and goes back to the early 1980s, when it was …

Prostaglandin F2αand its analogue latanoprost, both prostanoid FP receptor agonists,
reduce the intraocular pressure mainly by enhancing uveoscleral outflow. Changes in the …

Background Topical prostaglandin F 2α isopropyl ester increases uveoscleral outflow in
monkeys and humans. Objective To investigate the effects of prostaglandin F 2α isopropyl …

Prostaglandins are small pro-inflammatory molecules derived from arachidonic acid that
play roles in a multitude of biological processes including, but not limited to, inflammation …