In the burgeoning field of epigenetics, there are several methods available to determine the
methylation status of DNA samples. However, choosing the method that is best suited to …

Major histocompatibility complex (MHC) molecules are key players in initiating immune
responses towards invading pathogens. Both MHC class I and class II genes are present in …

Even though pancreatic ductal adenocarcinoma (PDAC) is associated with fibrotic stroma,
the molecular pathways regulating the formation of cancer associated fibroblasts (CAFs) are …

Background DNA methylation and the Polycomb repression system are epigenetic
mechanisms that play important roles in maintaining transcriptional repression. Recent …

BACKGROUND & AIMS: Alterations in methylation of protein-coding genes are associated
with Barrett's esophagus (BE) and esophageal adenocarcinoma (EAC). Dysregulation of …

Emerging evidence suggests that poor glycemic control mediates post-translational
modifications to the H3 histone tail. We are only beginning to understand the dynamic role of …

DNA methylation patterns in the genome both reflect and help to mediate transcriptional
regulatory processes. The digital nature of DNA methylation, present or absent on each …

Aberrant methylation of genomic DNA has been reported in many cancers. Specific DNA
methylation patterns have been shown to provide clinically useful prognostic information …

While DNA methylation plays a role in T-helper (Th) cell maturation, its potential
dysregulation in the non-atopic Th1-polarized systemic inflammation observed in obesity …

Background DNA methylation is a major epigenetic mechanism altering gene expression in
development and disease. However, its role in the regulation of gene expression during …