Fibroblast activation protein-α (FAP) is a type-II transmembrane serine protease expressed
almost exclusively to pathological conditions including fibrosis, arthritis, and cancer. Across …

Immuno-positron emission tomography (immunoPET) is a paradigm-shifting molecular
imaging modality combining the superior targeting specificity of monoclonal antibody (mAb) …

Fibroblast activation protein (FAP), a membrane-anchored peptidase, is highly expressed in
cancer-associated fibroblasts in more than 90% of epithelial tumors and contributes to …

Cardiac injury remains a major cause of morbidity and mortality worldwide. Despite
significant advances, a full understanding of why the heart fails to fully recover function after …

The tumor stroma, which accounts for a large part of the tumor mass, represents an attractive
target for the delivery of diagnostic and therapeutic compounds. Here, the focus is notably …

Tumors form a complex environment consisting of a variety of non-malignant cells.
Especially cancer-associated fibroblasts have been shown to have an important role for …

For over 40 years, 18F-FDG has been the dominant PET tracer in neurology, cardiology,
inflammatory diseases, and, most particularly, oncology. Combined with the ability to …

IgG4-related disease (RD) is characterized by lymphoplasmacytic infiltration enriched in
IgG4-positive plasma cells and variable degrees of fibrosis with a characteristic storiform …

Cancer-associated fibroblasts (CAFs) are generally associated with poor clinical outcome.
CAFs support tumor growth in a variety of ways and can suppress antitumor immunity and …

Immuno-positron emission tomography (immunoPET) with 89Zr-labeled antibodies has
shown great potential in cancer imaging. It can provide important information about the …