Female fertility is determined to a large extent by the quality (developmental competence) of
the oocyte as reflected in its ability to undergo meiosis, be fertilized, and give rise to a …

Vertebrate organ laterality is manifested by the asymmetric morphogenesis and placement
of inner organs. Asymmetric induction of the Nodal signaling cascade in the left lateral plate …

The fibroblast growth factors (FGFs) represent one of the relatively few families of
extracellular signalling peptides that have been shown in recent decades to be key …

Establishment of the left-right (LR, sinistral, dextral) body axis in many vertebrate embryos
relies on cilia-driven leftward fluid flow within an LR organizer (LRO). A cardinal question is …

The phenomenal migratory and differentiation capacity of neural crest cells has been well
established across model organisms. While the earliest stages of neural crest development …

Mutations in the GJA1 gene coding for connexin43 (Cx43) cause oculodentodigital
dysplasia (ODDD), a pleiotropic human disorder with characteristic morphologic anomalies …

In the mouse, the initial signals that establish left-right (LR) asymmetry are determined in the
node by nodal flow. These signals are then transferred to the lateral plate mesoderm (LPM) …

Organ left-right (LR) asymmetry is a conserved vertebrate feature, which is regulated by left-
sided activation of Nodal signaling. Nodal asymmetry is established by a leftward fluid-flow …

A common element during early left–right patterning of the vertebrate body is left-sided
nodal expression in the early-somite stage lateral plate mesoderm. Leftward cell movements …

A cilia-driven leftward flow of extracellular fluid breaks bilateral symmetry in the dorsal
midline of the neurula stage vertebrate embryo. The left-specific Nodal signaling cascade in …